MMP-9及其抑制剂TIMP-1在非小细胞肺癌中的表达及其与病理特征的相关性研究  

Expression of MMP-9 and TIMP-1 in Non-Small-Cell Lung Cancer and its Relationship with Clinical Pathological Features

作　　者：杨波[1] 盛辉[1] 苑春莉[2] 

机构地区：[1]吉林大学第一医院呼吸内科,吉林长春130021 [2]吉林大学第一医院妇产科,吉林长春130021

出　　处：《中国实验诊断学》2009年第9期1166-1167,共2页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅基金(200505182)

摘　　要：目的研究基质金属蛋白酶-9(MMP-9)和组织基质金属蛋白酶抑制剂-1(TIMP-1)在人非小细胞肺癌(NSCLC)组织中的表达及其与肺癌分期、分化程度和淋巴结转移等病理特征的相关性。方法通过免疫组织化学方法检测非小细胞肺癌组织和癌周组织中MMP-9和TIMP-1的蛋白表达,进行统计学处理。结果MMP-9和TIMP-1在各种不同病理类型的NSCLC组织中有不同程度的表达,在肺癌组织中的表达强于癌周肺组织。MMP-9和TIMP-1在腺癌中的表达强于鳞癌,在不同分化程度的肺癌组织中的表达没有统计学差异,在合并淋巴结转移的肺癌组织中表达较高。结论MMP-9及其特异性抑制剂TIMP-1参与了NSCLC的发生发展过程,MMP-9/TIMP-1表达失衡是NSCLC发生发展的关键。Objective To study the expression of metalloproteinase 9 and tissue inhibitors of metalloproteinase 1 in Non-smallcell lung cancer（NSCLC）, and its relationship with clinical pathological features. Methods The expression of MMP-9 and TIMP-1 in NSCLC and para-cancer pulmonary tissue were tested by immunohistochemical stain. Results The positive expression of MMP-9 and TIMP-1 in specimen was yellow,in cellular plasma. MMP-9 and TIMP-1 express in all types of tissue, strongest in adenocarcinoma, lower in squamous carcinoma, lowest in para-cancer pulmonary tissue. There was no significantly different between well-moderately differented NLCSC and poorly differented NLCSC. There was significantly different between pulmonary tissue with and without lymph node transfer. Conclusion MMP-9 and TIMP-1 may take part in the progress of NSCLC. The inbalaneed expression of MMP-9/TIMP-1 protein is the key enzyme of NSCLC invasion.

关 键 词：非小细胞肺癌 基质金属蛋白酶-9(MMP-9) 组织基质金属蛋白酶抑制剂-1(TIMP-1) 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]