^ωN—硝基左旋精氨酸对大鼠脑缺血后脑区一氧化氮生成的影响  

The Influence of ~ωN-nitro-L-arginine on the production of Nitric Oxide at Brain Regions After Cerebral Ischemia in Rats

作　　者：张洪[1] 慕容慎行[1] 刘友尧[2] 许国英[1] 吴秀丽[1] 

机构地区：[1]福建医科大学附属第一医院 [2]福建医科大学生化教研室

出　　处：《海峡药学》1998年第1期3-4,共2页Strait Pharmaceutical Journal

摘　　要：用荧光法研究ωN－硝基左旋精氨酸（L－NNA）对大鼠脑缺血后大脑皮层、海马、纹状体和小脑中一氧化氮（NO）的变化，结果显示L－NNA可明显减少缺血10min不同脑区NO的含量（P＜0．05或P＜0．01）；左旋精氨酸可部分逆转L－NNA的作用，使NO的含量增加（P＜0．05或P＜0．01）。提示L－NNA可减少脑缺血时NO的过量生成而具有潜在的治疗作用。Using fluorometric method,we study the influence of ωN-nitro-L-arginine on the production of nitric oxide (NO)at cerebral cortex hippocampus, striaum and cerebellum after cerebral ischemia in rats. The results showed that pretreated with L-NNA (1mg/kg,ip)significantly decreased the amount of NO at four brain regions at 10 minute ischemia (P<0.05 or P <0.01)- L-Arg (300mg/kg, ip )can partly reverse the amount of NO at four brain regions at 10 minute ischemia when it was given with L-NNA(P<0. 05 or P<0.01 ). These results indicated that L-NNA can markly attenuate the overproduction of No after cere-bral ischemia and has potential therapeutic effect for cerebral ischemia.

关 键 词：脑缺血 一氧化氮 ^ωN 硝基左旋精氨酸 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]