S100P在膀胱移行细胞癌中的表达与意义  

Expression of S100P in Bladder Transitional Cell Carcinoma and Its Significance

作　　者：谢宇[1] 杨罗艳[1] 江勃年[2] 谭春祈[2] 周晓[2] 

机构地区：[1]中南大学湘雅二医院泌尿外科,湖南长沙410011 [2]湖南省肿瘤医院,湖南长沙410006

出　　处：《医学临床研究》2009年第9期1651-1652,共2页Journal of Clinical Research

摘　　要：【目的】探讨S100P在膀胱移行细胞癌（BTCC）组织中的表达与意义。【方法】应用免疫印迹法检测45例BTCC及15例正常膀胱组织中S100P的表达。【结果】膀胱肿瘤中S100P蛋白表达高于正常膀胱组织中S100P的表达（P〈0．05）；在中低分化膀胱肿瘤组中S100P的表达高于高分化膀胱肿瘤组中S100P的表达（P〈O．05）；在浸润性膀胱肿瘤组中S100P的表达高于浅表性膀胱肿瘤组中S100P的表达（P〈O．05）。【结论]S100P在BTCC的发生、发展中起重要作用。[Objective]To investigate the expression of S100P in bladder transitional cell carcinoma（BTCC） and its significance. [Methods]Western blot was used in detecting the expression of S100P in 45 BTCC and 15 normal bladder tissue. [Resuhs]The expression of SLOOP protein in normal bladder tissue was lower than that in BTCC（ P 〈0.05）. The expression of SLOOP protein in GI carcinoma was lower than that in G Ⅱ-GⅢ carci- noma（ P 〈0.05）. The expression of S100P protein in superficial tumor was lower than that in invasive tumor （ P 〈0.05）. [Conclusion] S100P may play an important role in the carcinogenesis of BTCC.

关 键 词：癌 移行性细胞/病理学 膀胱肿瘤/病理学 神经组织蛋白质S100/生物合成 

分 类 号：R737.14[医药卫生—肿瘤]