T-PSA，F-PSA联合骨扫描对前列腺癌早期骨转移诊断中的意义  

Clinical Significance of Serum PSA, FPSA and Bone Scintigraphy for Diagnosis of Early Skeletal Metastasis in Prostatic Cancer

作　　者：余剑英[1] 林英[1] 谭政良[1] 雷萌[1] 

机构地区：[1]中南大学湘雅医院核医学科,湖南长沙410008

出　　处：《医学临床研究》2009年第9期1677-1679,共3页Journal of Clinical Research

摘　　要：【目的】分析血清总前列腺特异性抗原（TPSA）和游离前列腺特异性抗原（F-PsA）及放射性核素骨显像对前列腺癌早期骨转移的诊断价值。【方法】选择80例前列腺癌患者，70例良性疾病患者全部进行血清PSA，FPSA检测，并同时对80例临床确诊的前列腺癌患者进行放射性核素全身骨显像。另选择60例健康男性检测血清PSA，FPSA结果作为对照组。并计算FPSA／PsA比值。【结果】前列腺癌骨转移组患者血清PSA，FPSA结果显著高于良性疾病患者及正常健康男性（P〈0．01）。【结论]PSA，FPSA检测联合骨显像对前列腺癌早期骨转移具有重要意义。[Objective] To evaluate the value of prostate specific antigen （PSA, FPSA） and bone scintigraphic imaging in diagnosis of early skeletal metastasis of prostatic cancer. [Methods] Eighty patients with prostatic cancer, 70 patients with benign prostate disease and 60 healthy men were examined for serum levels of PSA and FPSA. At the same time, 80 patients with prostatic cancer were examined with bone scintigraphy. The FPSA/PSA ratio was calculated. [Results] Serum levels PSA and FPSA in skeletal metastasis of prostatic cancer were significantly higher than those in patients without skeletal metastasis, benign prostate patients and healthy men （ P 〈0.01） [Conclusion] Combined determination of PSA, FPSA and skeletal scintigraphic ima- ging have clinical significance in early skeletal metastasis of prostate cancer.

关 键 词：前列腺肿瘤/诊断 骨肿瘤/继发性 前列腺特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]