晚期上消化道肿瘤的内镜下局部化疗  

ENDOSCOPIC LOCAL CHEMOTHERAPY ON ADVANCED MALIGNANT TUMORS IN THE UPPER ALIMENTARY TRACT

作　　者：张志坚[1] 张捷[1] 高河元[1] 谢雨党[1] 黄云生[1] 刘英[1] 

机构地区：[1]南京军区福州总医院消化内科

出　　处：《中国内镜杂志》1998年第4期19-20,共2页China Journal of Endoscopy

摘　　要：３１例各种晚期上消化道恶性肿瘤患者，以生长方式分为隆起型（１７例），平坦型（１０例）和溃疡型（４例）。在内镜下以丝裂霉素，５－氟脲嘧啶，羟基喜树碱等药于病灶处行局部化疗。结果示：患者梗阻症状明显改善，尤以肿块型为最显著（Ｐ＜０．０１）；中位生存期延长至（１２．４±４．７）月，没有出现明显的副作用及并发症，结合使用肿瘤坏死因子，微波治疗可提高疗效。结果表明：对于不能手术的晚期上消化道恶性肿瘤患者。Thirty-one patients with various advanced malignant tumors of the upper digestive tract were divided into three types according to their endoscopic characteristics, which included eminence type (17 cases), flat type (19 cases) and ulcer type (4 cases). Fluorouracil, mitomycin-c and 10 hydroxy camptothecinum were injected into lesions as chemotherapy during endoscopy. Obstructive symptoms improved significantly after treatment and the median survival period was prolonged to 12.4±4.7 months. There were no general or local side effects or complications. The clinical effects would be better if tumor necrosis factor (TNF) and microwave were applied simultaneously. The results indicate that endoscopic local chemotherapy is an effective palliative treatment for advanced unresectable malignant tumours of the upper alimentary tract with no side effects or comlications.

关 键 词：内镜 上消化道肿瘤 药物疗法 晚期 

分 类 号：R735.05[医药卫生—肿瘤]