β-环糊精包合广藿香和橘红挥发油的工艺研究  

Study on the Inclusion of Volatile Oil Extracted from Herba Pogostemonis and Exocarpium citri by β-Cyclodextrin

作　　者：穆启运[1] 阮新民[1] 

机构地区：[1]广州中医药大学第二临床医院,广东广州510120

出　　处：《中药材》2009年第9期1454-1457,共4页Journal of Chinese Medicinal Materials

基　　金："十一五"国家科技支撑计划"重大疑难病中医防治研究"项目(2006BA104A00)

摘　　要：目的:考察用β-环糊精包合护心颗粒剂中广藿香和橘红的挥发油的工艺条件。方法:以包合物的收率和油转化率的综合评分作为评价指标,选择挥发油与β-环糊精的用量比、β-环糊精与加水量之比及研磨时间为主要影响因素,进行L9(34)正交试验,优化包合挥发油的工艺条件。结果:最佳包合工艺条件为挥发油与β-环糊精的用量比为1∶10,β-环糊精与加水量之比为1∶3,研磨时间为40 min。结论:广藿香和橘红挥发油的β-环糊精包合工艺合理可行。Objective ： To investigate the inclusion technology conditions of volatile oil extracted from Herba Pogostemonis and Exocarpium citri in Huxin Fang granules by β-cyclodextrin. Methods ： The orthogonal design was used. The percent conversion of the oil in inclusion and the yield of inclusion complex were the indices to determine the factors containing the ratio of the oil to β-cyclodextrin, the ratio of β-cyclodextrin to water and the grinding time of the mixture of the oil,β-cyclodextrin and water. Results： The optimum conditions for the inclusion were as follows ： the ratio of the oil to β-cyclodextrin was 1 ： 10, the ratio of β-cyclodextrin to water was 1 ： 3, and the grinding time was 40 min. Conclusion： The optimum conditions for the inclusion were steady and feasible.

关 键 词：广藿香 橘红 挥发油 Β-环糊精 包合物 

分 类 号：R943[医药卫生—药剂学]