苯并咪唑类药物研究进展  

Advances in the research of benzimidazole drugs

作　　者：孟江平[1] 耿蓉霞[1] 周成合[1] 甘淋玲[2] 

机构地区：[1]西南大学化学化工学院,重庆400715 [2]西南大学药学院,重庆400715

出　　处：《中国新药杂志》2009年第16期1505-1514,共10页Chinese Journal of New Drugs

基　　金：人事部回国人员重点项目(2002-99);重庆市自然科学基金(2007BB5369;2006BB4341);西南大学基金(XSGX0602;SWUB2006018)

摘　　要：苯并咪唑类化合物具有广泛的生物活性,临床上使用含有苯并咪唑结构片段的药物众多,其研究与开发活跃,进展迅速。本文综述了苯并咪唑类化合物在组胺受体拮抗剂、质子泵抑制剂、抗高血压、抗寄生虫、抗菌、抗真菌、抗病毒、抗癌等领域的研究与开发进展状况。Benzimidazole compounds exhibit a large range of biological activities and so far various types of benzimidazole drugs have extensively been used in clinic. Much attention has increasingly been paid toward the research and development of benzimidazole compounds as drugs, and the progress is quite fast. This paper reviewed recent advances in the research of benzimidazole compounds as histamine receptor antagonists, proton pump inhibitots, antihypertensive, antiparasitic, antibacterial, antifungal, anticancer and antiviral agents.

关 键 词：苯并咪唑 拮抗剂 质子泵抑制剂 抗高血压 抗寄生虫 抗菌 

分 类 号：R914.4[医药卫生—药物化学]