乳房外Paget病32例临床与组织病理分析  

Study on clinical and histopathological features of 32 patients with extramammary Paget disease

作　　者：朱小红[1] 李明 王利军[1] 杨莉佳[1] 

机构地区：[1]南京医科大学附属无锡第二医院皮肤科,江苏无锡214001

出　　处：《临床皮肤科杂志》2009年第10期639-641,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨乳房外Paget病的临床、组织病理学特征、恶性程度与预后。方法:收集32例乳房外Paget病患者资料,观察和分析其临床和组织病理学特征,并用免疫组化检测其的表达。结果:发病率男高于女,临床误诊率高,术后易复发,免疫组化CK7、EMA、CEA表达阳性,32例乳房外Paget病中P53、bcl-2有不同程度的阳性表达,且显著高于对照组(P<0.05)。结论:乳房外Paget病为低度恶性的皮肤肿瘤,有特殊的临床及组织病理特点,免疫组化提示有腺体分化能力,可判断恶性程度及预后。首选手术治疗,需长期随访。Objective： To investigate the clinical and histopathological features, severity of malignancy and prognosis of extramammary Paget disease（EMPD）. Methods： Clinical manifestations and histopathological findings were analyzed. The expression of CK7, EMA, CEA, p53 and bcl-2 was detected with immunohistochemical assay. Results： There were more males patients than females（27 versus 5） in 32 cases, with average disease-course at 2.35 years （5 months to 9 years）. All the 32 patients were misdiagnosed as other diseases at the first; and all of them without viscera involvement. Recurrence after excision was found in 9 out of 32 cases. The expression levels of p53 and bcl-2 were higher than those in the controls （P 〈 0.05）. Conclusions： The incidence of EMPD of males was higher than females. The misdiagnosis rate of EMPD was high, and recurrence rate was high after operation. Extensive excision of the lesions with long-term follow-up is the first choice in the treatment of extramammary Paget disease.

关 键 词：PAGET病 乳房外 临床分析 组织病理 

分 类 号：R730.261[医药卫生—肿瘤]