黄芪多糖联合达英-35对多囊卵巢综合征患者胰岛素抵抗、雄激素及脂代谢的影响  

Influence of Astragalus Polysaccharides Plus Diane-35 on Insulin Resistance and Androgen Levels and Lipid Metabolism of Patients with Polycystic Ovary Syndrome

作　　者：罗金[1] 尹太郎[1] 王雅琴[1] 杨菁[1] 徐望明[1] 李凤和[1] 苏红[1] 龙文[1] 李爱斌[1] 胡静[1] 

机构地区：[1]武汉大学人民医院生殖医学中心/武汉大学人民医院生殖医学研究室,湖北武汉430060

出　　处：《中国误诊学杂志》2009年第28期6812-6814,共3页Chinese Journal of Misdiagnostics

基　　金：武汉市科技公关项目(编号:200860423222)

摘　　要：目的:探讨黄芪多糖和达英-35联合应用对多囊卵巢综合征(PCOS)胰岛素抵抗、雄激素水平及脂代谢的影响。方法:对32例PCOS患者联合应用黄芪多糖和达英-35共3个月,观察治疗前后血性激素、胰岛素敏感性及血脂的改变。结果:治疗后患者血清空腹胰岛素水平、LH/FSH比值、T、A、DHEAS均显著降低(P<0.01),胰岛素敏感指数显著升高,血T-CHO、Lp(a)降低(P<0.01),HDL-C显著升高,TG也有轻度降低,差异具有统计学意义(P<0.05)。结论:黄芪多糖联合达英-35可有效改善PCOS患者胰岛素抵抗和高雄激素状态及血脂代谢,可为PCOS治疗的又一选择。Objective：To investigate the effection of astragalus polysaccharides plus diane-35 on insulin resistance.androgen levels and lipid metabolism of patients with polycystic ovary syndrome （PCOS）. Methods： 32 women with PCOS participated in the study and were administered with combined application of astragalus polysaccharides and diane-35 for 3 months. Sex hormones ,insulin sensitivity and blood lipid were evaluated before and after the therapy. Results ： After the treatment, fasting serum insulin levels, LH/FSH ratio, T, A, DHEAS, blood T-CHO and Lp （a） decreased significantly（P〈0.01） ,in the opposite ,insulin sensitivity index and HDL-C increased significantly,while TG has lightly reduced,and the difference was significant（P〈0. 05）. Conelusion：Astragalus polysaecharides plus diane-35 can be effective in improving insulin resistance,high androgen hormone status and lipid metabolism in patients with PCOS,and it may be alternative for PCOS.

关 键 词：多囊卵巢综合征/药物疗法/代谢 黄芪多糖/治疗应用 动力蛋白ATP酶/治疗应用 胰岛素抗药性 雄激素类/代谢 脂类/代谢 人类 女(雌)性 

分 类 号：R737.31[医药卫生—肿瘤]