静脉滴注木糖醇和葡萄糖对2型糖尿病患者血糖波动的影响  

Comparison of the influence of intravenously infused xylitol and glucose on blood glucose variability in type 2 diabetic patients

作　　者：朱佳花[1] 刘幼硕[1] 王艳姣[1] 汪化文[1] 赵红峰[1] 黄武[1] 王翼[1] 詹俊鲲[1] 

机构地区：[1]中南大学湘雅二医院老年内分泌科,长沙410011

出　　处：《中华临床营养杂志》2009年第4期201-204,共4页Chinese Journal of Clinical Nutrition

基　　金：湖南省科技厅科技计划项目（2007-FJ4166,2007-JT2009）

摘　　要：目的比较静脉滴注木糖醇和葡萄糖对2型糖尿病患者血糖波动的影响，以期为糖尿病患者静脉载体液的选择提供依据。方法稳定期2型糖尿病患者22例，采用自身对照方法，分别在试验第1、2、3天上午9：00-11：00匀速静脉滴注生理盐水200ml、10％木糖醇溶液100ml、5％葡萄糖200ml＋胰岛素2．5U，同时采用动态血糖监测系统每5min记录1次血糖，比较血糖变化情况。结果静脉滴注生理盐水、木糖醇和葡萄糖＋胰岛素2h及输液结束后1h共180min内血糖平均值分别为（7．74±0．84）mmol／L、（7．83±1．01）mmol／L和（7．84±1．37）mmol／L（P〉0．05），血糖曲线下面积分别为（1429．16±340．79）mmol·min／L、（1449．25±192．28）mmol·min／L和（1447．59±317．94）mmol·min／L（P〉0．05），血糖变异度分别为10．9％、12．88％和17．47％。结论静脉滴注木糖醇后血糖略有下降，对血糖波动性的影响较葡萄糖注射液小。小剂量木糖醇注射液可替代葡萄糖注射液作为稳定期2型糖尿病患者的静脉载体液。Objective To investigate the influence of intravenously infused xylitol and glucose on blond glucose variability in type 2 diabetic patients. Methods Totally 22 patients （ 18 males and 4 females） with type 2 diabetes mellitus were recruited. From 9 am to 11 am, all the subjects were randomly administered with one of the three solutions at constant speed on consecutive days： 0.9% normal saline 200 ml, 10% xylitol 100 ml, and 5% glucose 200 ml ＋ 2.5 U insulin. The blood glucose concentration was determined every 5 minutes after infusion by continuous glucose monitoring system （CGMS）. The variability of blood glucose was compared among these 3 days using different solutions. Results The means, the areas under curve （ AUC ）, and the coefficients of variation （CV） of blood glucose of normal salines, 10% xylitol, and 5% glucose ＋ insulin were as follows. Means： （7.74 ± 0.84） mmol/L, （7.83 ±1.01） mmol/L, and （7.84±1.37） mmol/L （P〉0.05）; AUCs： （1 429. 16 ±340. 79 ）mmol . min/L, （ 1 449. 25± 192. 28 ） mmol.min/L, and （ 1 447.59±317. 94 ）mmol.min/L （ P 〉 0. 05 ） ; and CVs： 10. 9%, 12.88%, and 17.47%. Conclusions Xylitol can lower the blood glucose a little but without significant difference. It has little effect on blood glucose variability of patients with type 2 diabetes mellitus and can be safely used for rehydration.

关 键 词：木糖醇 血糖波动 动态血糖监测 2型糖尿病 

分 类 号：R587[医药卫生—内分泌]