复方补骨脂对羟基脲家兔激素水平的影响  

The influence of fructus psoralea on the hormone of rabbits injected with hydroxyurea

作　　者：孙朝阳[1] 刘长江[2] 高玛丽[1] 

机构地区：[1]西安交通大学医院,陕西西安710049 [2]西安交通大学体育部,陕西西安710049

出　　处：《现代中西医结合杂志》2009年第30期3669-3671,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察复方补骨脂对羟基脲家兔激素水平的影响。方法将白兔21只随机分成3组：正常组每日按10mL／kg体质量喂饲生理盐水；模型组每日以10mL／kg体质量喂饲50g／L羟基脲悬浊液；中药组每日按5mL／kg体质量喂饲100g／L羟基脲悬浊液，另加补肾阳中药煎剂5mL／kg体质量。3组共饲喂7～10d。放免方法测定血清雌二醇（E2）、睾酮（T）水平。结果模型组家兔造模后血中E2含量从造模前（2．10±0．84）μg／L降低至（0．25±0．09）μg／L，两者比较有显著性差异（P〈0．01）；T含量由造模前（10．5±0．38）ng／L降低至（0．36±0．18）ng／L，两者比较有显著性差异（P〈0．05）；E2／T比值造模前后变化无显著性差异。中药组造模加中药治疗后岛含量为（1．92±0．92）μg／L，与治疗前比较无显著性差异（P〉0．05）；血中T水平为（1．28±1．24）ng／L，与治疗前比较无显著性差异（P〉0．05）。结论复方补骨脂对羟基脲家兔激素水平有明显的保护作用。Objective It is to observe the influence of fructus psoralea on the hormone of rabbits injected with hydroxyurea. Methods 21 rabbits were divided into 3 groups randomly with 7 cases each group. According to the weight of the rabbit, the normal group was fed with physiological saline 10 mL/kg; the model group was fed with 50 g/L hydroxyurea suspension 10 mL/kg; the Chinese medicine group was fed with 100 g/L hydroxyurea suspension 5 mL/kg and 5 mL/kg kidney yang reinforcement medicine decoction. All groups were treated for 7 days. The levels of serum estrogen （E2） and serum testosterone （T） were detected by radioimmunoassay. Results In the model group, the level of E2 was （2.10 ± 0.84） μg/L before treatment and was reduced to （0.25±0.09） μg/L after the treatment, there was significant difference （P 〈 0.01）. The level of T was reduced from （1.05±0.38） ng/L to （0.36 ±0.18） ng/L after the treatment, there was significant difference （P〈 0.05）. There was no significant difference on the value of E2/T before and after treatment. In the Chinese medicine group, the level of E2 was （1.88± 0.56） μg/L before treatment and was （ 1.92 ± 0.92） μg/L after the treatment, there was no significant difference （P 〉 0.05）. The level of T in the blood before the treatment was （1.54 ± 1.02） ng/L, and was （1.28 ± 1.24） ng/L after the treatment, there was no significant difference. Conclusion Fructus psoralea has an obvious protection effect on the rabbits injected with hydroxyurea.

关 键 词：复方补骨脂 羟基脲 家兔 激素 

分 类 号：R-332[医药卫生]