HO-1与MRP2在原发性胆囊癌组织中的表达和意义  

Expression and significance of HO-1 and MRP2 in primary gallbladder carcinoma

作　　者：莫非[1] 王健生[1] 吴文安[1] 张佳[1] 王昌燕[1] 段小艺[1] 

机构地区：[1]西安交通大学医学院第一附属医院,陕西西安710061

出　　处：《现代肿瘤医学》2009年第10期1897-1900,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(30600744)

摘　　要：目的:检测血红素加氧酶-1(heme oxygenase,HO-1)与多药耐药相关蛋白2(multidrug resistance-associated protein2,MRP2)在原发性胆囊癌组织中的表达,探讨其与胆囊癌发生、发展的关系。方法:采用免疫组化SP法检测67例原发性胆囊癌患者中HO-1和MRP2的表达水平。结果:原发胆囊癌组织HO-1和MRP2表达的总阳性率分别为73.1%、77.6%。其中腺癌的阳性率为76.7%和80%。依据病理分级,HO-1和MRP2表达水平由高到低分别为III级>II级>I级,且具有统计学差异(P=0.028,P=0.023);HO-1、MRP2的阳性表达与年龄、性别等临床特征无相关性;HO-1和MRP2表达之间具有良好的相关性(r=0.324,P=0.005)。结论:HO-1和MRP2在原发性胆囊癌组织高表达,对胆囊癌的发生、发展提供有利条件,二者之间表达具有良好的相关性。Objective：To detect expression of heme oxygenase （ HO - 1 ） and multidrug resistance - associated protein 2 （ MRP2 ）, and investigate its significance in primary gallbladder carcinoma. Methods ： Sixty - seven patients with primary gallbladder carcinoma entered this study. Immunohistochemistry （SP assay） and image analysis was used to semiquantitatively detect the expression of HO - 1 and MRP2 protein. Results ： Positive expression rates of HO - 1 and MRP2 were 73.1% and 77.6% respectively in primary gallbladder carcinoma. The expression of HO -1 and MRP2 had a significantly correlation with pathological grading （P =0. 028 ,P = 0. 023 ）. HO -1 and MRP2 expression level showed no statistical associated with sex and age. Conclusion： Both of HO - 1 and MRP2 overexpressed in primary gallbladder carcinoma and may play certain role in development of primary gallbladder carcinoma.

关 键 词：血红素加氧酶-1 多药耐药相关蛋白2 原发性胆囊癌 免疫组织化学 

分 类 号：R730.3[医药卫生—肿瘤]