大肠早期癌症血卟啉和组织卟啉浓度研究(英文)  

Concentration of protoporphyrin Ⅸ in cancer tissues and blood in patients with colorectal cancer at early stage

作　　者：贾泽明[1] 万小平[1] 

机构地区：[1]中南大学湘雅医院肝胆肠外科研究中心,长沙410008

出　　处：《中南大学学报（医学版）》2009年第9期846-849,共4页Journal of Central South University ：Medical Science

摘　　要：目的:研究癌变肠道局部卟啉浓度差异并阐述其在自体荧光光谱诊断中的应用。方法:检测30例大肠癌病人,30例正常人血原卟啉Ⅸ浓度差异,以及60例大肠组织(30例正常;30例异常)原卟啉Ⅸ的含量。结果:癌症病人血液中血原卟啉IX明显高于正常人(P<0.05),大肠癌组织原卟啉IX含量大于大肠正常组织的含量(P<0.05)。结论:癌变肠道局部卟啉含量异常升高,是大肠早期癌症自体荧光诊断技术(644.3±5.7)nm处特异荧光峰值的物质基础。Objective To determine the concentration difference in protoporphyrin in cancerous intestine and to discuss its application in laser-induced autofluorescence diagnosis for colorectal cancer at early stage. Methods We detected the concentration of protoporphyrin Ⅸ in 30 patients with colorectal cancer and 30 control patients, as well as that in 60 cases of intestinal tissues （30 control tissues and 30 cancer tissues）. Results The concentration of blood protoporphyrin Ⅸ in patients with colorectal cancer was significantly higher than that in the controls （ P 〈 0.05 ）. Protoporphyrin Ⅸ concentration in the cancer tissue was significantly higher than that in the control tissues （P 〈 0.05 ）. Conclusion That the concentration of protoporphyrin in cancerous intestine becomes abnormally high may be the material basis for spectrum intensity peak of （644.3 ± 5.7 ） nm in laser-induced autofluorescence diagnosis for colorectal cancer at early stage.

关 键 词：大肠早癌 自体荧光 诊断 卟啉Ⅸ 

分 类 号：R735.34[医药卫生—肿瘤]