抗精神病药物对精神分裂症患者生活质量影响的1年随访研究  

Effect of antipsychotic drugs on life quality of schizophrenic patients:one year follow-up study

作　　者：房茂胜[1,2] 李乐华[2] 赵靖平[2] 陈红辉[1] 叶萌[1] 国效峰[2] 陆铮[3] 孙学礼[4] 王传跃[5] 谢世平[6] 胡斌 郭田生 马崔[9] 汪波[10] 吕路线 刘娜[3] 邓红[4] 陈琦[5] 尚晓芳[6] 龚发金 张喜艳 何小林[9] 周建初[10] 张迎黎 

机构地区：[1]武汉市精神卫生中心,武汉430022 [2]中南大学湘雅二医院精神卫生研究所,长沙410011 [3]上海精神卫生中心,上海200030 [4]四川大学华西医院心理卫生中心,成都610041 [5]北京安定医院,北京100088 [6]南京脑科医院,南京210029 [7]江西省精神病院,南昌330029 [8]湖南脑科医院,长沙410007 [9]广州脑科医院,广州510370 [10]重庆市精神卫生中心,重庆401147 [11]河南省精神病院,河南新乡453002

出　　处：《中南大学学报（医学版）》2009年第9期850-855,共6页Journal of Central South University ：Medical Science

基　　金："十五"国家科技攻关计划项目(2004BA720A22)~~

摘　　要：目的:比较氯丙嗪、舒必利、氯氮平、利培酮、奥氮平、喹硫平、阿立哌唑等7种抗精神病药物长期服用对精神分裂症患者生活质量的影响。方法:对1 227例病程小于5年服用7种药物之一作为维持治疗的精神分裂症患者进行为期1年的随访,在基线、随访12个月进行健康状况调查问卷(SF-36)评定。结果:与基线相比,7组药物1年末生活质量都有很大的提高。不同药物对躯体疼痛、精力和精神健康因子的改善存在显著差异(P<0.05),以奥氮平和喹硫平对生活质量的改善最为明显。结论:长期服用抗精神病药物能不断提高精神分裂症患者的生活质量。非典型抗精神病药物,尤其是奥氮平和喹硫平,对生活质量的改善要优于传统抗精神病药物。Objective To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole. Methods A total of 1 227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey （SF-36） at the baseline and at the end of 1 year. Results The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health （ P 〈 0.05 ） among these antipsychotic drugs. Conclusion All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.

关 键 词：精神分裂症 抗精神病药物 生活质量 SF-36 

分 类 号：R749.3[医药卫生—神经病学与精神病学]