食管癌放疗敏感性相关肿瘤标记物研究  

Advancement of tumor markers associated with radiosensitivity of esophageal carcinoma

作　　者：伊艳[1] 巩合义(综述)[1] 李宝生(审校)[1] 

机构地区：[1]山东省肿瘤防治研究院放疗六科,济南250117

出　　处：《国际肿瘤学杂志》2009年第9期686-689,共4页Journal of International Oncology

基　　金：山东省医药卫生科研项目（2007hz102）

摘　　要：与食管癌放疗敏感性相关的肿瘤标记物按存在部位可分为组织学肿瘤标记物和血清学肿瘤标记物，前者包括乏氧诱导因子-1α、环氧合酶-2、p53蛋白、p21蛋白、表皮生长因子受体、增殖细胞核抗原、Survivin蛋白等，后者包括血管内皮生长因子、细胞角蛋白19片段抗原21-1等，对其检测有利于预测食管癌放疗敏感性并制定合理的治疗方案。Tumor markers associated with the radiosensitivity of esophageal carcinoma are mainly divided into tissue tumor markers and serum tumor markers. Tissue tumor markers include hypoxia inducible factor- 1α, cyclooxygenase-2, p53 protein, p21 protein, epidermal growth factor receptor, Ki67 and Survivin, while serum tumor markers include vascular endothelial growth factor, squamous cell carcinoma-antigen and so on. Detection of these markers may be helpful for predicting the radiosensitivity of esophageal carcinoma and making optimal treatment plans.

关 键 词：食管肿瘤 肿瘤标记 生物学 辐射耐受性 

分 类 号：R735.1[医药卫生—肿瘤]