小儿原发性肾病综合征Tamm-Horsfall蛋白与β_2微球蛋白水平改变的意义  

Changes of Tamm-Horsfall protein and β_2microglobulin level in children with primary nephrotic syndrome.

作　　者：梁大才[1] 李成荣 李永柏 雷培芸 杨渝生 

机构地区：[1]重庆医科大学儿童医院

出　　处：《中国实用儿科杂志》1998年第5期279-281,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的：研究小儿原发性肾病综合征（ＰＮＳ）Ｔａｍｍ－Ｈｏｒｓｆａｌ蛋白（ＴＨＰ）与β２微球蛋白（β２ＭＧ）水平改变的意义。方法：对小儿ＰＮＳ６０例活动期和缓解期血ＴＨＰ、β２ＭＧ水平和尿ＴＨＰ、β２ＭＧ排泄量进行测定。结果：血ＴＨＰ、β２ＭＧ值均在正常范围。尿ＴＨＰ排泄量持续增高，且以激素治疗耐药和依赖者增高为著。β２ＭＧ排泄ＰＮＳ－Ｉ完全正常；ＰＮＳ－Ⅱ活动期增高，缓解期恢复正常；ＰＮＳ－Ⅲ持续增高。肾合成ＴＨＰ功能增强，原因不明。尿β２ＭＧ排泄增多可能系近曲小管功能受损所致。Objective:To study the significance of TammHorsfall protein (THP) and β2microglobulin (β2MG) changes in children with primary nephrotic syndrome(PNS).Methods:The levels of blood THP and β2MG,quantities of THP and β2MG excreted in urine were determined in 60 cases of PNS during remission and active phase.Results:The blood levels of THP and β2MG were all normal,while the quantity of THP excreted in urine increased persistantly.The excretion was especially obvious in patients who were dependent or resistant to prednisone treatment.The quantity of β2MG excreted in urine was normal in PNS group Ⅰand increased during active phase and returned to normal during remission in PNS group Ⅱ;and increased persistantly in PNS group Ⅲ.β2MG excretion increased in urine may be due to damage to the function of proximal convoluted tubules.Conclusion:THP and β2 MG detection is of great value to PNS.

关 键 词：Β2微球蛋白 原发性 肾病综合征 THP 儿童 

分 类 号：R726.920.4[医药卫生—儿科]