A Facile Procedure for Conjugate Addition of Amines to Electron Deficient Alkenes with Metal Oxide as Catalyst  

作　　者：LIANG Xue-zheng GAO Shan YANG Jian-guo 

机构地区：[1]Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China [2]Energy Institute, Department of Materials Science and Engineering, Pennsylvania State University, PA 16802, USA

出　　处：《Chemical Research in Chinese Universities》2009年第5期744-747,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Key Project of Scientific;Technical Supporting Programs Funded by Ministry of Science & Technology of China(No.2006BAE03B06)

摘　　要：A novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. A series of metal oxides was synthesized for catalyzing the conjugate addition of amines and alkenes. After optimizing the reaction conditions, SrO was chosen as the most efficient catalyst for the reactions. The results show that the catalyst is very efficient for the conjugate addition of amines to electron deficient alkenes with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity and applicability to large-scale reactions are the key features of this methodology.A novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. A series of metal oxides was synthesized for catalyzing the conjugate addition of amines and alkenes. After optimizing the reaction conditions, SrO was chosen as the most efficient catalyst for the reactions. The results show that the catalyst is very efficient for the conjugate addition of amines to electron deficient alkenes with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity and applicability to large-scale reactions are the key features of this methodology.

关 键 词：Heterogeneous Conjugate addition CHEMOSELECTIVE Metal oxide SOLVENT-FREE 

分 类 号：O643.36[理学—物理化学] TM862[理学—化学]