子宫内膜癌Ras癌基因产物P21蛋白质的表达  

Expression of Oncogene K Ras Product P21 Protein in the Tissues of Endometrial Carcinoma

作　　者：桂黎明[1] 肖子文[1] 陈卓[1] 

机构地区：[1]贵阳医学院附院妇产科

出　　处：《贵阳医学院学报》1998年第3期269-271,共3页Journal of Guiyang Medical College

摘　　要：为了解ＫＲａｓ癌基因表达产物Ｐ２１蛋白质与子宫内膜癌产生和发展的关系，用免疫组织化学ＳＰ染色法对４８例子宫内膜癌、２０例子宫内膜增殖症和２０例正常子宫内膜组织进行检测。３５例子宫内膜癌组织Ｐ２１蛋白质表达阳性（阳性率为７２９％）；２０例子宫内膜增殖症和２０例正常子宫内膜组织Ｐ２１蛋白质表达阴性。Ｐ２１蛋白质表达随癌组织病理分级和侵肌程度上升增强。ＫＲａｓ癌基因产物Ｐ２１蛋白质的表达与子宫内膜癌的发生、发展和预后有关，对指导临床治疗有意义。To determine the expression of oncogene K ras product P21 protein and analyse their correlation with the endometrial carcinoma, expression of P21 protein were detected by immunohistochemical SP method in paraffin embeded tissues from 48 cases of Endometrial Carcinoma, 20 cases of endometrial hyperplasia and normal endometrium. Incidences of expression of P21 protein was 72.9%,but no expression in endometrial hyperplasia and normal endometrium. Expression of P21 protein was enhanced with the increasing of grading and invasive depthe. The positive expression of P21 protein in endometrical carcinoma is rele Vant to carcinogenesis, tumor progression and prognosis of patients with endometrial carcinoma.

关 键 词：子宫内膜肿瘤 RAS基因 P21基因 

分 类 号：R737.330.2[医药卫生—肿瘤]