血清神经元特异性烯醇酶和胃泌素用于肺癌的临床价值  

Clinical Value of Measurement of Serum Neuron Specific Enolase and Gastrin for Lung Cancer

作　　者：周建奖 王仁敏[1,2] 润丹 

机构地区：[1]贵州省肿瘤研究所 [2]贵阳医学院附院肿瘤科

出　　处：《贵阳医学院学报》1998年第3期285-287,共3页Journal of Guiyang Medical College

基　　金：贵州省卫生厅科研基金

摘　　要：检测３０例正常对照、２５例良性肺疾病、５５例非小细胞肺癌（ＮＳＣＬＣ）和１５例小细胞肺癌（ＳＣＬＣ）患者血清神经元特异性烯醇酶（ＮＳＥ）和胃泌素及其在治疗前后的动态变化，结果显示，血清ＮＳＥ和胃泌素在４组间差异有极显著性（Ｐ＜０００１），ＮＳＥ均值分别为８２２、１０８４、１４６４和３２００μｇ／Ｌ，胃泌素均值分别为５９４７、８２００、２２１５３和３５６８６ｎｇ／Ｌ。以２０３μｇ／Ｌ（ＮＳＥ）和８１４ｎｇ／Ｌ（胃泌素）为正常参考值上限，ＮＳＥ阳性率分别是８０％（ＳＣＬＣ）和１４５４％（ＮＳＣＬＣ），胃泌素分别是８０％（ＳＣＬＣ）和６３６３％（ＮＳＣＬＣ）。肺癌治疗后血清ＮＳＥ和胃泌素在ＳＣＬＣ组均显著下降（Ｐ＜０００１），而ＮＳＣＬＣ组仅有胃泌素降低（Ｐ＜０００１）。因此，ＮＳＥ主要用于ＳＣＬＣ的诊断、组织学分型及疗效监测，而胃泌素可以用于各型肺癌，两者联合可以提高临床应用价值。To study the clinical value of measurement of serum neuron specific enolase (NSE) and gastrin for lung cancer, serun NSE and gastrin were measured with ABC ELISA and Radioimmunoassay in 30 healthy persons(C),25 patients with benign pulmonary diseased (BPD),55 patients with non small cell lung cancer (NSCLC) and 15 patients with small cell lung cancer(SCLC). The results revealed that serum concentrations of NSE and gastrin had significant differences in the four groups (P<0.001).The mean values of NSE and gastrin in C,BPD,NSCLC,SCLC were 8.22,10.84,14.64,32.00 μg/L and 59.47,82.00,221.53,356.84 ng/L,respectively. If values above 20.3 μg/L(NSE) and 81.4 ng/L (gastrin) were considered abnormal, the positive rates of NSE and gastrin in SCLC, NSCLC were 80%, 14.54% and 80%, 63.63% respectively. After the patients with lung cancer were treated, serum levels of NSE and gastrin decreased in SCLC significantly (P<0.001),but levels of gastrin decreased only in NSCLC(P<0.001).The results suggest that NSE may be used in diagnosing, histological typing and therapy monitoring in SCLC,and gastrin in various lung cancer. Combined determinations of NSE and gastrin may raise their value in clinical use.

关 键 词：神经元 特异性 烯醇酶 胃泌素 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]