载药多孔微球的吸附及缓释性能研究  

Study of adsorption and controlled release performance of actives-carrying porous microspheres

作　　者：李璐[1] 程江[2] 杨卓如[2] 

机构地区：[1]华南农业大学食品学院,广东广州510640 [2]华南理工大学化工与能源学院,广东广州510640

出　　处：《日用化学工业》2009年第5期313-316,共4页China Surfactant Detergent & Cosmetics

基　　金：广东省自然科学基金资助项目(05006556)

摘　　要：采用改进的二步种子溶胀聚合法制得粒径15μm内的多孔聚合物微球,以Parsol1789为模型组分,研究了多孔聚合物微球的活性物吸附能力以及体外释放性能,重点研究了多孔微球的比表面积、孔径和粒径对微球吸附和释放速度的影响。结果表明,比表面积大的多孔微球具有更高的平衡吸附量,由于Parsol1789分子体积较大,孔径对吸附量和释放速率都表现出了较大的影响,而随着微球粒径的减小,Parsol1789呈现更快的释放速度。从Parsol1789的释放结果可以看出,10 h后约释放负载活性物总质量的90%左右。Porous microspheres were prepared by modified two -step seed swelling polymerization method. Parsol1789 was used as the model component. Actives adsorption capacity and its vitro - releasing performance of the porous mierospheres were studied with the effects of specific surface area, pore diameter and particle size on the adsorption capacity and releasing speed focused. Results showed that the equilibrium adsorption capacity increases with increase of surface area. Since the volume of the molecule of Parsol 1789 is rather big, the effect of pore diameter on adsorption capacity and releasing speed is significant. Following the decline of particle size,the releasing speed of Parsol1789 becomes faster. After 10 h, 90% of the loaded actives have been released.

关 键 词：化妆品添加剂 多孔微球 吸附 活性物 Parsol1789 缓释 

分 类 号：TQ658[化学工程—精细化工]