小剂量5-氟尿嘧啶联合顺铂治疗低KPS评分晚期肿瘤  

Low-dose of 5-Fluorouracil and Cisplatin for treatment of 22 low KPS cases with advanced cancer

作　　者：魏涛[1] 邹三鹏[1] 宁宇[1] 陈维[1] 

机构地区：[1]南方医科大学附属花都区人民医院,广东广州510800

出　　处：《基层医学论坛》2009年第22期675-676,共2页The Medical Forum

摘　　要：目的观察小剂量5-Fu联合CDDP持续滴注治疗低KPS评分晚期肿瘤的近期疗效与毒副反应。方法22例Ⅳ期肿瘤患者,KPS评分40～60分,分别予以CDDP6mg/m2,d1～5;5-Fu170mg/m·2d,d1～7;均通过化疗微量泵持续滴注,每21d为1个周期,连用2个周期以上评价疗效。结果总的有效率为18.2%;症状改善率45.5%,其中对胃肠道癌症状改善率较高为58.8%。主要毒副反应为Ⅰ～Ⅱ度胃肠道反应。结论小剂量5-氟尿嘧啶联合顺铂持续滴注治疗低KPS评分晚期恶性肿瘤安全有效。Objective To evaluate the efficacy and toxicity of Continuous Venous Infusion of Low-dose of 5-Fluorouracil and Cisplatin on advanced low KPS cancer . Methods 22 patients with advanced cancer and low KPS （40～60）were received 5-Fu 170 mg/m^2·d,civ ,d1～7; and CDDP （6 mg/m^2·d）,civ,d1～5. The treatment was given every 21 days,and 2 cycle were given to all cases. Results The overall response rate was18.2%（4/22）. The rate of improving was 45.5%,and to the gastrointestinal cancer was 58.8%. The major toxic effect was （grade Ⅰ～Ⅱ） gastrointestinal side-effects. Conclusion Continuous venous Infusion of low-dose of 5-Fluorouracil and Cisplatin is an efficient and well-tolerated chemotherapeutic approach in the patients with advanced and low KPS cancer.

关 键 词：低剂量化疗 低KPS评分 晚期恶性肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]