子宫颈癌新辅助化疗的疗效  

Effect of neoadjuvant chemotherapy on cervical carcinoma

作　　者：曹兰琴[1] 黎欣[1] 李新国[1] 张怡[1] 

机构地区：[1]中南大学湘雅医院妇产科,长沙410008

出　　处：《中南大学学报（医学版）》2009年第6期527-530,共4页Journal of Central South University ：Medical Science

基　　金：湖南省科技计划项目(2008RS4018)~~

摘　　要：目的:研究宫颈癌新辅助化疗的疗效及与临床资料之间的关系。方法:选择行新辅助化疗的Ib2～IIIa期宫颈癌患者97例,分析化疗后的近期疗效,影响疗效的有关因素和术后病理结果。结果:新辅助化疗的近期有效率为86.6%;与疗效有关的因素为临床分期和病理类型;新辅助化疗后84例患者可以手术,术后病理降级的有17例,术后淋巴结阳性者19例,宫旁浸润者6例;随访中1例患者术后1年内死亡,5例复发,余患者均健在。结论:局部晚期宫颈癌新辅助化疗效果好,新辅助化疗后手术能改善患者预后,提高术后生存率。Objective To investigate the effect of neoadjuvant chemotherapy on cervical carcinoma and its association with clinical data.Methods A total of 97 patients with stage Ib2～IIIa of cervical cancinoma were treated with neoadjuvant chemotherapy.The effect of chemotherapy,factors associated with outcome of chemotherapy,and histology were analyzed.Results Effective rate of chemotherapy was 86.6% which was associated with clinical stage and histology.Eight-four patients received radical hysterectomy.The histological grade of 17 patients was lowered,lymph nodes in 19 patients were positive,and 6 patients had parametrium invasion.One patient died within 1 year after the operation,and 5 patients recurred.Conclusion The effect of neoadjuvant chemotherapy for locally advanced cervical cancinoma is good.Surgery after chemotherapy can improve the prognosis and 5-year survival rate.

关 键 词：宫颈癌 新辅助化疗 子宫切除术 

分 类 号：R737.33[医药卫生—肿瘤]