大鼠面神经切断后其神经元形态变化的研究  

Neuronal Morphology of Facial Nucleus after Facial Nerve Cut Off in Rats

作　　者：李宗芳[1] 叶峻杰 刘流[3] 王福科[3] 

机构地区：[1]昆明医学院第一附属医院磁共振室,云南昆明650032 [2]云南省人口和计划生育科学技术研究所,云南昆明650021 [3]昆明医学院第一附属医院口腔颌面外科,云南昆明6500321

出　　处：《昆明医学院学报》2009年第9期45-48,共4页Journal of Kunming Medical College

摘　　要：目的观察面神经高位切断后其神经元的形态改变.方法建立SD大鼠面神经高位切断模型后行HE、TB和TUNEL染色,观察健侧面神经元及术后1、3周时伤侧面神经元的形态改变.结果健侧和术后1周伤侧面神经元均未见明显凋亡,术后3周伤侧面神经元见明显凋亡.结论面神经损伤后3周可导致伤侧面神经元出现明显凋亡.Objective To detect the neuronal morphology of facial nucleus after facial nerve cut off. Methods The model of SD rats suffered facial nerve cut off was established. Then HE, TB and TUNEL staining were made to observe the neuronal morphology of facial nucleus on the healthy side and injured side of 1 and 3 week group. Results There were no obvious neuronal apoptosis of facial nucleus on the healthy side and injured side of 1 week group. But on the injured side of 3 week group there was remarkable neuronal apoptosis of facial nucleus. Conclusion 3 weeks after facial nerve cut off neurons of facial nucleus may be induced to remarkable apoptosis.

关 键 词：面神经损伤 神经元 凋亡 

分 类 号：R745.13[医药卫生—神经病学与精神病学]