莫西沙星三联疗法对根除幽门螺杆菌的多中心临床观察  

Multicenter Clinical Observation of 7-day Moxifloxacin-based Triple Therapies for Hpylori Eradication

作　　者：代薇[1] 李世媛 周竹[3] 

机构地区：[1]昆明医学院第一附属医院消化内科,云南昆明650032 [2]东川区第二人民医院,云南东川654100 [3]昆明医学院第一附属医院肾内科,云南昆明650032

出　　处：《昆明医学院学报》2009年第9期92-94,共3页Journal of Kunming Medical College

摘　　要：目的观察以莫西沙星为基础的7d三联疗法对根除Hpylori感染的临床效果.方法采用随机对照设计,214例Hpylori(+)患者分为两组,莫西沙星组:奥美拉唑20mgqd、莫西沙星0.4gqd、替硝唑0.5gbid;对照组:奥美拉唑20mgqd、克拉霉素0.5gbid、阿莫西林1.0gbid治疗7d,治疗结束4周后通过14C-UBT检查Hpylori是否根除.结果莫西沙星组Hpylori根除率为87.9%,对照组根除率为72.6%.两组之间的Hpylori根除率有显著性差异(χ2=6.779,P<0.05).结论以莫西沙星为基础的7d三联疗法是可供选择的Hpylori根除方案.AIM To observe the clinical effect of 7-day moxifloxacin-based therapies for Hpylori eradication. Methods In this random control study, 214 H pylori-positive＇ patients were divided into moxifloxacin （esomeprazole 20 mg qd, moxifloxacin 0.4 g qd, tinidazole 0.5 g bid） group and observe （esomeprazole 20 mg qd, Clarithromycin 0.5 g bid, arnoxicillin 1.0 g bid） group. The patients in both groups were treated for 7 days. H pylori status was assessed 4 weeks after the end of treatment by 14 C urea breath test. Results The treatment was completed in all the 214 patients. The rates of H pylori eradication in moxifloxacin group and observe were 87.9% and 72.6%, respectively, and there was statistical difference between them （ Х^2 = 6.779, P 〈 0.05）. Conclusion Seven-day moxifloxacin-based triple therapy is a feasible H pylori eradicati on method.

关 键 词：幽门螺杆菌 莫西沙星 7d三联疗法 

分 类 号：R573.1[医药卫生—消化系统]