MCM5和PCNA在鼻咽低分化鳞癌中的表达及意义  

Expression of minichromosome maintenance protein 5 and PCNA in NPC and its significance

作　　者：朱秀梅[1] 钟良清[1] 

机构地区：[1]广东省高州市人民医院病理科,广东高州525200

出　　处：《中国当代医药》2009年第18期36-38,共3页China Modern Medicine

摘　　要：目的:检测鼻咽低分化鳞癌组织中微小染色体维持蛋白5(MCM5)的表达意义及与细胞增殖核抗原(PCNA)的关系。方法:采用免疫组织化学S-P法检测50例鼻咽低分化鳞癌、20例鼻息肉组织中MCM5及PCNA的表达情况。结果:MCM5与PCNA在鼻咽低分化鳞癌中的表达均高于鼻息肉组织(P<0.01):鼻咽低分化鳞癌中,MCM5的表达高于PCNA(P<0.05),两者之间呈正相关(r=0.839 7,P<0.01);MCM5与PCNA在鼻咽低分化鳞癌中的表达在性别、年龄、淋巴结转移方面的差异不具有统计学意义(P>0.05)。结论:MCM5在鼻咽癌组织中高表达,可作为鼻咽低分化鳞癌的标志物。Objective： To study the expression of minichromosome maintenance protein 5 （MCMS） in nasopharyngeal carci noma tissue and its significance, and to analyze the correlation between MCM5 and PCNA. Methods：The expression of MCM5 and PCNA were detected with Streptavidin-Peroxidase （S-P）. Results： The expressions of MCM-5 and PCNA were both higher in cancer than those in tissues of rhino polypus, and the labeling index of MCM5 in nasopharyngeal carcinoma was higher than that of PCNA. A positive correlation was found between MCM5 and PCNA. Labeling index of MCM5 showed no significant correlation with patient age, gender, and lymph node metabasis. Conclusion： MCM5 has a high expression in nasopharyngeal carcinoma tissue and it is more sensitive than PCNA as an indicator for pathological diagnosis of NPC.

关 键 词：鼻咽癌 微小染色体维持蛋白5 细胞增殖核抗原(PCNA) 

分 类 号：R73-354[医药卫生—肿瘤]