阿立哌唑治疗老年期精神分裂症的研究  

A comparative study of aripiprazole and haloperidol in the treatment of senile schizophrenia

作　　者：张保利[1] 兰志敏[1] 冯锋[1] 

机构地区：[1]北京回龙观医院老年科,北京100096

出　　处：《中国当代医药》2009年第18期47-48,共2页China Modern Medicine

摘　　要：目的:探讨阿立哌唑与氟哌啶醇对老年期精神分裂症的疗效和安全性。方法:将86例老年期精神分裂症患者随机分为两组,分别选用阿立哌唑和氟哌啶醇治疗,疗程12周,疗效评定采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效和不良反应。结果:治疗12周后,两组PANSS评分较治疗前均显著下降。阿立哌唑组有效率69.76%,显效率88.37%,氟哌啶醇组有效率65.12%,显效率86.05%,两组间比较,差异无统计学意义(P>0.05),阿立哌唑组不良反应少而轻。结论:阿立哌唑与氟哌啶醇治疗老年期精神分裂症均有肯定疗效,阿立哌唑不良反应轻,安全性好。Objective： To compare the efficacy and safety between aripiprazole and haloperidol in the treatment of senile schizophrenia. Methods： 86 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or haloperidol treatment respectively. The periods of treatment were 12 weeks. The positive and negative symptom scale. （PANSS） and treatment emergent symptom scale （TESS） were used to evaluate the efficacy and side effects. Results： 12 weeks after treatment than before treatment PANSS score had dropped significantly in the two groups. Aripiprazole group efficiency was 69.76%, effective rate was 88.37%, haloperidol group were 65.12% and 86.05%, the two groups had no significant difference （P＇M3.05）, Aripiprazole group adverse reactions and less light. Conclusion： Aripiprazole and Haloperidol have defined effect in the treatment of senile schizophrenia. Aripiprazole has slight side and good safety.

关 键 词：阿立哌唑 氟哌啶醇 老年期精神分裂症 副反应量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]