DJ-1基因:抗帕金森病药物作用的可能新靶点  

DJ-1 gene:a new potential target of drugs for Parkinson's disease

作　　者：张宏宁[1,2] 安春娜[1,2] 蒲小平[1,2] 

机构地区：[1]北京大学天然药物与仿生药物国家重点实验室,北京100191 [2]北京大学药学院分子与细胞药理学系,北京100191

出　　处：《中国药理学通报》2009年第9期1138-1141,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2004CB518902)

摘　　要：帕金森病是一种常见于中老年人群的神经系统退行性疾病,其发病与环境因素和遗传因素相关。DJ-1的基因突变和氧化损伤分别与家族性和散发性帕金森病相关。DJ-1基因突变或氧化损伤导致帕金森病的机制包括氧化应激、线粒体损伤和蛋白酶体损伤。此外,DJ-1还是散发性帕金森病的生物标记物,并且有可能成为抗帕金森病药物作用的潜在新靶点。Parkinson＇ s disease （PD） is a neurodegenerative disease commonly found in middle-aged and elderly people, and its onset is attributable to both genetic and environmental factors. The gene mutation and oxidative damage of DJ-1 correlate with familial and sporadic PD, respectively. The mechanisms by which DJ-1 gene mutation and oxidative damage lead to PD in-clude oxidative stress, mitochondrial dysfunction and proteasome dysfunction. Furthermore, DJ-1 is a biomarker of sporadic PD and it may become a new potential target of anti-PD drugs.

关 键 词：DJ-1 帕金森病 靶点 氧化应激 分子伴侣 转录调节 

分 类 号：R-05[医药卫生] R394.2