肺穿刺液基细胞学与组织病理学对比分析  

Comparative analysis of lung puncture liquid-based cytology and histopathology

作　　者：涂频[1] 吉耘[1] 祁正茂[1] 刘红娟[1] 季洪爱[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,江苏南京210002

出　　处：《医学研究生学报》2009年第9期959-960,I0004,共3页Journal of Medical Postgraduates

基　　金：江苏省自然科学基金资助项目(批准号:BK2003074)

摘　　要：目的:膜式超薄液基细胞学(TCT)检测是近年来应用于细胞病理学诊断的一项新技术。文中分析肺穿刺液基细胞学与组织病理学诊断的符合情况。方法:408例CT导引下经皮肺穿刺活检组织经固定、包埋、切片、染色后光镜观察,并将穿刺针涮洗液行液基细胞学检测,比较液基细胞学和组织病理学的符合性。结果:408例肺穿刺中,液基细胞学诊断癌148例(36.3%),疑癌32例(7.8%),异形38例(9.3%),阴性190例(46.6%);组织病理学诊断癌183例(44.9%),疑癌21例(5.1%),异形22例(5.4%),阴性182例(44.6%)。2种检测方法结果相关(P<0.001)。结论:液基细胞学能制出良好的涂片,可以准确地反映肺病变情况,组织病理学联合液基细胞学能提高对肺疾病的诊断率。Objective ： The Thinprep liquid - based cytology test （TCT） is a new technique applied to cytopathologie diagnosis in recent years. The purpose of this study was to analyze the diagnostic coincidence between lung puncture liquid-based cytology and histopathology. Methods： A total of 408 tissue specimens obtained by CT-guided percutaneous translung biopsy were observed under the optical microscope after fixation, embedding, sectioning and staining, and the cells in the washing fluid for puncture needles were detected by TCT. Then the diagnostic coincidence was analyzed between cytological and pathological biopsies. Results： Of the 408 cases detected by liquid-based cytology, 148 （36.3%） were diagnosed as cancer, 32 （7. 8%） as suspected cancer, 38 （9. 3%） as heterocyst and 190 （44.9%） were negative, as compared with 183 （44. 9%）, 21 （5. 1%）, 22 （5. 2%） and 182 （44.6%） by histopathology. The results showed a correlation between the two methods （P 〈 0. 001 ）. Conclusion： TCT helps make good smears and accurately reflect pulmonary lesions, and it can improve the diagnosis of pathological changes in the lungs when combined with histopathology.

关 键 词：肺穿刺 液基细胞学 组织病理学 

分 类 号：R361.2[医药卫生—病理学]