Survivin在胆管癌表达与预后的关系  

Nuclear surviving expression predicts poor prognosis in cholangiocarcinoma

作　　者：边伟[1] 刘三光[1] 路文彦[1] 刘建华[1] 

机构地区：[1]河北医科大学第二医院肝胆外科,石家庄050000

出　　处：《中华实验外科杂志》2009年第10期1335-1337,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨胆管癌患者中Survivin的表达在提示预后中的作用。方法48例手术切除的胆管癌标本，应用免疫组织化学技术（SP法）检测Survivin基因在48例胆管癌中的表达。Survivin的表达分别描述为阴性或弱阳性和强阳性。结果Survivin在胞质和细胞核表达例数分别为26例和22例患者。细胞质中强阳性表达为12例，而细胞核强阳性表达的则有8例。细胞核强阳性表达的患者平均存活期为10个月，明显低于弱阳性表达的患者（19个月，P〈0．05）。Cox比例风险率模型的多因素分析方法证实存在2个独立的预后因素：Survivin细胞核表达（P〈0．05）和远处转移（P〈0．05）。结论胆管癌中Survivin的细胞核表达可提示较差的预后。Objective To study the prognostic role of survivin expressed in cholangiocarcinoma. Methods Forty-eight cases of cholangiocarcinoma were studied. Immunohistochemistry was performed u- sing a monoclonal antibody to survivin. Survivin expression was described as absent or weak and strong. Results Cytoplasmic and nuclear survivin expression was seen in 26 and 22 patients respectively. Strong cytoplasmic survivin expression was seen in 12 cases and strong nuclear survivin in 8. Patients with strong nuclear survivin had a median survival of 10 months, significantly lower than for patients with weak nuclear survivin expression （19months,P 〈 0.05）. Multivariate analysis using the Cox-proportional hazards model identified 3 important prognostic predictors ： nuclear survivin （ P 〈 0.05 ） and presence of metastasis （ P 〈 0.05）. Conclusion Nuclear survivin expression in cholangiocarcinoma may predict a poor prognosis.

关 键 词：SURVIVIN 胆管癌 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]