老年脑梗死病人血清细胞因子含量及其动态变化  

Content and change of cytokine factor in serum from aged cerebral infarction patients

作　　者：张清华[1] 崔元孝[1] 刘敬花[2] 郑茂永[1] 冯建利[1] 潘宁[1] 王晓红[1] 张桂茹[1] 

机构地区：[1]山东大学附属山东省立医院神经内科,山东济南250021 [2]山东省交通医院神经内科

出　　处：《中国老年学杂志》2009年第18期2310-2312,共3页Chinese Journal of Gerontology

基　　金：山东省卫生厅医药卫生科研项目(2003HZ103)

摘　　要：目的研究老年脑梗死病人血清中IL-6、TNF-α含量的动态变化及其与脑梗死体积及预后的关系。方法72例病人及70例健康对照者来自山东大学附属省立医院,均于出现症状24h内入组。在确诊当时及第1、2、3、4、6、10天各留取血液标本,测定血清IL-6、TNF-α水平。梗死体积为发病第7天CT测得。神经功能恢复评定标准为修正的Rankin等级评分。结果病例组入院时IL-6水平达到高峰(0.95±0.18)ng/L,至第3天又出现高峰(0.90±0.21)ng/L,各时点IL-6水平高于对照组(P<0.01),其含量与脑梗死体积及Rankin等级评分有相关性。各观察时点TNF-α与对照组无显著差别。结论IL-6能反映脑卒中时脑组织的损害程度,并且与病人预后密切相关,血清IL-6含量在发病早期升高,可以作为老年脑梗死早期敏感的诊断指标。Objective To explore the changes of IL-6, TNF-α in serum from aged cerebral infarction patients and the relationship between IL-6, TNF-α and cerebral infarction prognosis. Methods 72 patients and 70 healthy persons were selected from the affiliated provine hospital of shandong university, who were all selected into groups after appearance symptoms 24 hours. IL-6, TNF-α were measured on the same time of diagnosis and the 1st, 2nd, 3rd, 4th, 6th, 10th day. The volume of infarction was examined on 7th day by CT. Rankin grade mark was made as critial neural function recovery. Results IL-6 of patients reached the peak on the time of coming into hospital and the 3rd day during the hospital. The level of IL-6 in patients on all time point were all higher than that of healthy person （P 〈0. 01 ） , and its content had the relationship with the voluem of infarction and Rankin grade mark. There was no difference between the level of TNF-α on all time point and that of healthy person. Conclusions IL-6 can reflect the extent of damage of brain in cerebral infarction and has relationship with the patients＇ prognosis. IL-6 can be made as diagnostic indicator for aged early sensitive cerebral infarction, which raise in early stage of disease.

关 键 词：脑梗死 白介素-6 肿瘤坏死因子-Α 预后 脑梗死体积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]