骨髓间充质干细胞体外诱导分化为肝细胞的研究与进展  

Advance of bone mesenchymal stem cells differentiation into liver cells in vitro

作　　者：罗伟[1] 肖恩华[1] 

机构地区：[1]中南大学湘雅二医院放射科,湖南省长沙市410011

出　　处：《中国组织工程研究与临床康复》2009年第36期7155-7158,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30070235;30470508;30870695);湖南省自然科学基金重点项目(06JJ20081);湖南省自然科学基金项目(07JJ6040);长沙市科技计划重点项目(K071532-11)~~

摘　　要：骨髓间充质干细胞既具有自我更新的能力,也具有在合适的微环境里向多系横向分化的潜能,在体外可以被诱导分化为肝细胞,理论上可提供丰富的肝细胞来源。随着骨髓间充质干细胞研究的兴起,利用干细胞及器官重建治疗肝脏疾病成为一种新的治疗模式,其中寻找合适的体外诱导培养体系是当前骨髓间充质干细胞研究的焦点之一。文章较全面的总结了骨髓间充质干细胞在多种微环境下向肝细胞诱导分化的特点,各种诱导条件的优势以及存在的问题。Bone marrow mesenchyma stem cells are stem cells that occupy self-renewal and multiple differentiations into cells, which have been recognized as the optimal origin for liver cell. With an increasing number of studies addressing marrow mesenchyma stern cells, more attention has been drawn to treating liver disease using the stem cell and organ reconstruction, especially seeks for the appropriate in vitro induction system. This paper comprehensive summarized the differentiation characteristics of marrow mesenchyma stem cell under many kinds of micro environment, and explains the superiority, as well as existence question of each kind of induction condition.

关 键 词：骨髓间充质干细胞 诱导 肝细胞 

分 类 号：R394.2[医药卫生—医学遗传学]