激活骨髓加自体移植联用重组白细胞介素2治疗T细胞淋巴瘤生存期超过10年1例(英文)  

Bone marrow activation and autologous peripheral blood stem cell transplantation in combination with recombinant interleukin-2 application for treatment of T cell lymphoma in one case A follow-up of more than 10 years

作　　者：林丽娥[1] 姚红霞[1] 吴从明[1] 姚志明[1] 黄昭前[1] 符祥俊[1] 

机构地区：[1]海南省人民医院血液内科,海南省海口市570311

出　　处：《中国组织工程研究与临床康复》2009年第36期7183-7185,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：患者,男,33岁,发现腰部肿物2个月,行肿物切除病理提示为非霍奇金淋巴瘤,T细胞,免疫母细胞,血象大致正常,骨髓可见2%肉瘤细胞,诊断:非霍奇金淋巴瘤T细胞,Ⅳ期。予CHOP(环磷酰胺、阿霉素、长春新碱、强的松)等方案化疗4个月后,于1998-04行激活骨髓加自体外周血干细胞移植并联用重组白细胞介素2治疗。预处理方案为MACC方案(马法兰、阿糖胞苷,环磷酰胺,环己亚硝脲),移植+10d,中性粒细胞>0.5×109L-1,移植+16d,血小板>50×109L-1。移植+6d出现发热,血培养为大肠埃希秆菌,经抗生素治疗体温正常,症状消失。随访至今已10年10个月,仍无病生存,工作及生活正常。A 33-year-old male patient complained of presenting goiter on the low back area for 2 months. Pathological examinations of resected goiter suggested non-Hodgkin lymphoma and showed that T cells, immunoblasts, and hemogram were roughly normal, and 2% sarcoma cells could be found in bone marrow. Stage IV T-cell non-Hodgkin＇s lymphoma was diagnosed. Following 4 months of chemotherapy using CHOP protocol （cyclophosphamide, adriamycin, vincristine, and prednisone included）, the patient underwent bone marrow activation and autologous peripheral blood stem cell transplantation in combination with recombinant interleukin-2 application in April 1998. The preprocessing was performed under MACC protocol （L-sarcolysinum, cytarabine, cyclophosphamide, and Iomustine included）. Ten days after autologous stem cell transplantation, neutrophil concentration was 〉 0.5×10^9/L and sixteen days after transplantation, blood platelet concentration was 〉 50×10^9/L. Six days after transplantation, the patient exhibited fever, and E. coil infection was confirmed through blood culture. After antibiotic treatment, body temperature recovered to normal, and fever disappeared. The patient had been followed-up for 10 years and 10 months. During the follow-up period, he lived a normal life and work.

关 键 词：激活骨髓 自体干细胞移植 淋巴瘤 长期生存 

分 类 号：R394.2[医药卫生—医学遗传学]