基质金属蛋白酶-9及组织基质金属蛋白酶抑制剂-1在脑动静脉畸形血清中的表达及与出血的关系  

Expression of MMP-9, TIMP-1 in Blood Serum of CAVM Patients and Their Relationship with Hemorrhage

作　　者：邸飞[1] 陈彤岩[2] 赵继宗[1] 王硕[1] 赵元立[1] 张东[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,北京市100050 [2]首都医科大学附属北京天坛医院检验科

出　　处：《中国卒中杂志》2009年第9期752-756,共5页Chinese Journal of Stroke

摘　　要：目的研究基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)及组织基质金属蛋白酶抑制剂-1(tissue inhibitor of metalioproteinases-1,TIMP-1)在脑动静脉畸形(cerebullar arteriovenous malformations,CAVM)患者血清中的表达及其与出血的关系。方法选取48例脑动静脉畸形患者。按有无出血症状分为出血组及非出血组,并选取24例原发癫患者为正常对照组。对患者术前及术后3d、7d血清中的MMP-9和TIMP-1水平进行研究。结果术前出血组及非出血组中,MMP-9、TIMP-1含量均显著高于对照组(P<0.01),术后出血组及非出血组中,上述指标与术前相比有所下降,但仍高于同期对照组(P<0.01)。出血组及非出血组间,术前与术后MMP-9、TIMP-1含量均无统计学差异(P>0.05),但术前两组间MMP-9与TIMP-1之比值(MMP-9/TIMP-1)具有统计学差异(P<0.05)。结论MMP-9及TIMP-1与CAVM的发生发展有密切关系,MMP-9水平升高可能是TIMP-1合成和分泌的促进因素之一。MMP-9和TIMP-1比例失衡,可能是引起脑动静脉畸形出血的重要机制。Objective To research the expression of matrix metalloproteinase-9（MMP-9） and tissue inhibitor of metalloproteinase- 1 （TIMP- 1） in blood serum of cerebullar arteriovenous malformations（CAVM） and their relationship with hemorrhagic history. Methods 48 patients suffering from CAVM were studied, including 24 patients with hemorrhagic history（CAVM H group） and 24 patients without hemorrhagic history（CAVM N group）. 24 patients suffering from essential epilepsy were enrolled into control group（CG group）. We researched the expression of MMP-9,TIMP-1 in blood serum by immunohistochemistry. Results Compared with control samples, CAVM samples show a higher expression in MMP-9 and TIMP-1（P〈0.01）. There was no significant difference in levels of MMP-9, TIMP-1 （P〉0.05） between CAVM H Group and CAVM N Group. However, CAVM H Group showed a higher expression in MMP-9/TIMP-1 compared with CAVM N Group（P〈0.05）. Conclusion There is a close relationship between MMP-9, TIMP-1 and the growth, abnormal extension of vessels in CAVMs. MMP-9 is one of the factors to promote expression of TIMP-1. Perhaps disbalance of MMP-9 and TIMP-1 is an important reason of hemorrhage in CAVMs.

关 键 词：颅内动静脉畸形 脑出血 基质金属蛋白酶-9 组织基质金属蛋白酶抑制剂-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]