转录因子C/EBPβ的研究进展  

The Research Progress of Nuclear Transcription Factor C/EBPβ

作　　者：汪霞[1] 王振宝[1] 郑威楠[1] 韩虎[1] 蒋旭鹏[1] 张东辉[1] 潘泽民[1] 

机构地区：[1]石河子大学医学院生物化学与分子生物学教研室,新疆石河子832002

出　　处：《现代生物医学进展》2009年第16期3198-3200,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(No:30660193;30860302);教育部春晖计划资助(Z2006-1-83011)

摘　　要：C/EBPs增强子结合蛋白是核转录因子,其作用范围广泛,既参与正常的生理代谢过程,又与多种疾病的发生和发展相关,其作用方式多样,对转录有正、负调控作用。C/EBPβ是其第二位成员主要通过对靶细胞基因转录的调节,参与细胞的增殖与分化、肿瘤的发生与凋亡等重要生命活动;其功能受到蛋白酶降解、磷酸化、蛋白质相互作用等多种途径的调控。本文就C/EBPs的调控机理及其与肿瘤的关系综述如下。C/EBPs （CCAAT enhancer binding proteins） familiy are important transcription factors. They are not only involved in normal process ofphysiolgical metabolism, but also related to the occurrence and development of many kinds of disorders. C/EBPβ is the second member of C/EBPs, it plays important roles in numerous cellular responses by regulating the transcription of genes from target cells, including the cell proliferation and differentiation, tumorgenesis and apoptosis, inflammation. The fimctions of C/EBPs are regulated by proteolysis, phosphorylation, interaction between proteins, etc. In this paper, the research progress and relationship with diseases of C/EBPs were reviewed.

关 键 词：C/EBP增强子结合蛋白β 肿瘤 磷酸化 

分 类 号：Q75[生物学—分子生物学] R730[医药卫生—肿瘤]