阿司匹林与双嘧达莫预防缺血性脑卒中复发的临床观察  

Observation of aspirin plus dipyridamole in preventing recurrence of ischemic stroke

作　　者：韦志明[1] 陆凤机[1] 陆明智[1] 

机构地区：[1]广西壮族自治区隆安县人民医院内科,隆安532700

出　　处：《临床医学》2009年第10期9-11,共3页Clinical Medicine

摘　　要：目的观察阿司匹林与双嘧达莫预防缺血性脑卒中复发的临床疗效及安全性。方法将172例缺血性脑卒中患者随机分为观察组和对照组各86例,两组均给予常规康复治疗。观察组在此治疗基础上给予肠溶阿司匹林及双嘧达莫治疗;对照组则口服双嘧达莫,疗程均为1年。比较两组脑卒中复发率、生存质量、生活活动能力、血液流变学变化及不良反应。结果观察组脑卒中复发率为8.1%,明显低于对照组的19.8%(P<0.05);观察组患者生活质量指数明显高于对照组(P<0.01);观察组生活活动能力明显优于对照组(P<0.01);观察组血液流变学较对照组明显改善(P<0.01)。两组患者均未出现明显不良反应。结论联合应用阿司匹林与双嘧达莫预防脑卒中复发,能有效降低其复发率,提高患者生活活动能力和生活质量,安全性好,具有广阔的应用前景。Objective To observe the therapeutic effect and safety of aspirin plus dipyridamole in preventing recurrence of ischemic stroke. Methods One hundred and seventy - two cases with ischemic stroke were randomly divided into two groups ： observation group （86 cases） and control group （86 cases）. All patients were received conventional therapy. Aspirin and dipyridamole was taken in observation group while the patients in control group only took dipyridamole for 1 year. The recurrence rate, living quality, locomotor activity, hcmorheology and of two groups were compared. Results The recurrence rate of observation group（ 8.1% ） was significantly lower than that in control group（ 19.8% ） （ P 〈 0.05 ） ;the QLI score of observation group was significantly higher than that in control group （ P 〈 0.01 ） ; the ADL level in observation group was higher than that in control group（ P 〈0.01 ） ;the hemorheology change of observation group was more improve than that in control group（ P 〈 0.01 ）. No obvious adverse effect were observed. Conclusion The combination of aspirin and dipyridamole can prevent effectively the recurrence of ischemic stroke. It can improve the locomotor activity and living quality of patients with ischemic stroke.

关 键 词：缺血性脑卒中 阿司匹林 双嘧达莫 预防 复发 

分 类 号：R743.3[医药卫生—神经病学与精神病学]