助乳化剂对多囊脂质体影响的初步考察  

Preliminary Study on Influence of Co-emulsifi ers on Multivesicular Liposomes

作　　者：陈亭亭[1] 陆伟根[1] 王莉莉[1] 虞丽芳[1] 

机构地区：[1]上海医药工业研究院,药物制剂国家工程研究中心,上海200437

出　　处：《中国医药工业杂志》2009年第10期758-760,765,共4页Chinese Journal of Pharmaceuticals

基　　金："重大新药创新"科技重大专项(2009ZX09310-003)

摘　　要：以拓扑替康为模型药物,采用复乳法制备多囊脂质体,考察了分别以L-赖氨酸、聚乙烯醇和海藻酸钠为助乳化剂对脂质体粒径和包封率的影响。结果表明,三者均能作为助乳化剂得到多囊脂质体,但种类和用量对制品粒径和包封率均有显著影响。Multivesicular liposomes （MVLs） loaded with topotecan were prepared by double emulsification The effects of L-lysine, polyvinyl alcohol and sodium alginate as co-emulsifier on the diameter and encapsulation efficiency of the multivesicular liposomes were investigated. The results showed that the MVLs could be obtained with the three compounds as co-emulsifier. The particle size and encapsulation efficiency were affected by the type and amount of co-emulsifier significantly.

关 键 词：拓扑替康 多囊脂质体 助乳化剂 L-赖氨酸 聚乙烯醇 海藻酸钠 

分 类 号：R944.9[医药卫生—药剂学]