黄芪多糖的安全性研究  

Safety Evaluation of Astragalus Polysaccharide

作　　者：昭日格图[1] 娜日苏[1] 韩景芬[1] 麻春杰[2] 领小[1] 博日吉汗格日勒图 

机构地区：[1]内蒙古大学高分子化学及蒙药研究所,内蒙古呼和浩特010021 [2]内蒙古医学院中医学院,内蒙古呼和浩特010110

出　　处：《食品科学》2009年第19期309-313,共5页Food Science

基　　金：国家自然科学基金项目(30160103)

摘　　要：目的:研究黄芪多糖作为保健食品及药品使用的毒理学安全性。方法:利用大鼠急性毒性实验、小鼠骨髓细胞微核实验、小鼠精子畸变实验、Ames实验和大鼠30d喂养实验进行毒理学研究。结果:急性毒性实验表明黄芪多糖咀嚼片对雌、雄大鼠急性经口最大耐受量(MTD)均大于15.0g/kgbw,其剂量相当于人体推荐量的300倍,说明受试物属于无毒级物质。遗传毒性实验:小鼠骨髓细胞微核实验、小鼠精子畸变实验、Ames实验的结果皆为阴性,未显示出致突变性。30d喂养实验表明,5.00、2.50和1.25g/kgbw剂量时,对动物的身体、脏器的生长发育及血液生化指标等均无明显不良影响。结论:黄芪多糖具有较好的安全性,可作为保健食品及药品使用。Objective： To study toxicological safety ofAstragalus polysaccharide as a health food or drug. Methods： Acute toxicity test in rats, mouse bone marrow cell micronucleus test, mouse sperm aberration test, Ames test and 30-day feeding study in rats were carried out. Results： Acute toxicity test indicated that the acute, oral maximum-tolerated dosage （MTD） of ＂Astragalus polysaccharide mastication tablets＂ to male and female rats were both more than 15.0 g/kg bw, which were equivalent to 300 times of the recommended value to human body. Therefore, this subject can be recognized as a non-toxic substance. All results of genotoxicity tests, including mouse bone marrow cell micronucleus test, mouse sperm aberration test and Ames test were negative. This revealed that no mutation occurred. In addition, 30-day feeding study in rats demonstrated all the doses of 5.00, 2.50 and 1.25 g/kg bw did not offer distinct adverse effects on the body weight, organ growth and blood biochemical indicators. Conclusion： Astragalus polysaccharide can be used as a health food or drug due to its better safety.

关 键 词：黄芪多糖 安全性 毒理实验 

分 类 号：R114[医药卫生—卫生毒理学]