轻度血管性认知障碍患者内颞叶体积与记忆力的相关性研究  

Correlative Study of Medial Temporal Lobe Volumes and Memory Function in Mild Vascular Cognitive Impairment Patients

作　　者：崔金利[1] 印弘[1] 齐顺[1] 汤丽华[1] 邓艳春[2] 

机构地区：[1]第四军医大学西京医院放射科,陕西西安710032 [2]第四军医大学西京医院神经内科,陕西西安710032

出　　处：《实用放射学杂志》2009年第9期1231-1234,共4页Journal of Practical Radiology

基　　金：国家自然科学基金面上项目（编号：30872717）;陕西省科学技术研究发展计划项目（编号：2007K15-01）.

摘　　要：目的探讨轻度血管性认识障碍（mVCI）患者内颞叶体积和记忆功能改变的相关性。方法采用MRI技术测定32例mVCI患者和30例正常对照者杏仁核、海马及海马旁回体积。应用痴呆简易筛查量表（MMSE）和韦氏记忆量表评定受试者记忆功能。结果mVCI患者和正常对照组比较，杏仁核、海马及海马旁回体积无显著差异（P〉0．05）。右侧海马体积与再认评分呈正相关性（r=0．586，P=0．021）。左侧杏仁核与视觉再生评分呈负相关性（r=-0．400，P=0．043）。右侧海马旁回与联想学习评分呈正相关性（r=0．418，P=0．033）。结论mVCI患者的记忆功能已有损害。MRI检查与认知神经心理学的联合研究能为早期诊断mVCI提供有力的参考依据。Objective To study the correlation of medial temporal lobe volumes and memory in mild vascular cognitive impairment（mVCI）patients. Methods The volumes of amygdala, hippocampus and parahippocampal gyrus in 32 vMCI patients and 30 normal controls were measured with IBASPM technique. The memory function were assessed by WMS-RC testing in all subjects. Results The volumes of amygdala, hippocampus and parahippocampal gyrus had no significant difference between mVCI patients and normal control subjects （P〉0. 05）. The volume of right hippocampus was positively correlated with the recognition scores. The volume of right parahippocampal gyrus was positively correlated with the association study scores. Conclusion The patients with mVCI have the deficit in memory. The examination of psychometric testing and MRI test can offer a powerful reference for the early diagnosis of mVCI.

关 键 词：脑 血管性认知障碍 内侧颞叶 记忆 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]