CT引导下经皮^(125)I粒子猪胰腺内植入的实验研究  

CT-guided percutaneous interstitial implantation of ^(125)I seeds into the pancreas: an experimental study in pigs

作　　者：张峰[1,2] 张长宝[1] 田建明[1] 弓静[1] 孙高峰[1] 

机构地区：[1]第二军医大学长海医院放射科 [2]解放军105医院放射科

出　　处：《介入放射学杂志》2009年第9期688-690,共3页Journal of Interventional Radiology

基　　金：上海市科委基金(054119637);上海市领军人才基金(LJ06006)

摘　　要：目的评价CT引导下经皮穿刺猪胰腺内125I放射性粒子植入安全性。方法选取健康家猪12只,按照治疗后观察的时间不同分为6组,每组2只。治疗组植入放射性粒子,对照组植入粒子空壳。对照组分别于治疗后15、60 d处死动物,治疗组术后15、30、45、60和75 d影像学检查后分批处死动物,观察腹腔的变化;取胰腺、十二指肠、肝、肾等组织,行常规病理学检查。术前、术后24 h,7、15、21、30和60 d行血液学检查。结果所有125I粒子在CT引导下均成功植入猪胰腺内,随访表明无严重并发症发生。影像学及病理学发现,治疗组15 d时粒子周围胰腺组织出现坏死,45 d和60 d时坏死区明显增大,75 d坏死体积与60 d相仿;对照组粒子周围未见坏死。随访至75 d,相邻脏器十二指肠、胃、肝和肾脏没有发现渗出、出血和坏死等严重并发症。结论CT引导下经皮穿刺125I粒子胰腺内植入是安全可行的。Objective To investigate the feasibility and safety of percutaneous interstitial implantation of ^125I seeds into the pancreas of pig under CT-guidance. Methods Twelve healthy pigs were equally divided into 6 groups, ^125I seed implantation into the pancreatic tail under CT-guidance was performed in pigs of study groups （group A - E）, while ghost seeds that contained no radioactive materials were used in the control group （group F）. Imaging examination and laboratory tests, including serum amylase, hepatic and renal functions, were conducted before and 1, 7, 15, 21, 30, 60 days after the procedure. Every two pigs （group A - E） were sacrificed each time at 15, 30, 45, 60, and 75 days after treatment, and specimens of pancreas, duodenum, liver, kidney, etc. were collected and sent for pathologic examination. Results The ^125I seeds were successfully implanted in all pigs. During the follow-up period, no severe complications occurred. Imaging and pathologic studies demonstrated that in study groups necrosis of pancreatic tissue appeared around the implanted ^125I seeds in 15 days, the necrosis area increased significantly in 45 and 60 days, and in 75 days the necrosis size remained quite the same as seen in 60 days. No necrosis was found in the control group （group F） 60 days after treatment. No serious complications, such as effusions, hemorrhage or necrosis of the adjacent duodenum, stomach, liver or kidney, occurred 75 days after the treatment. Conclusion Percutaneous interstitial implantation of ^125I seeds into the pig＇s pancreas under CT-guidance is safe and feasible.

关 键 词：猪 猪胰腺 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]