弗林蛋白酶与心血管活性物质关系的研究进展  

Advance in the Relationship between Furin and Cardiovascular Active Material

作　　者：罗文利[1] 李南方[1] 洪静[1] 

机构地区：[1]新疆维吾尔自治区人民医院高血压科新疆高血压研究所,乌鲁木齐830001

出　　处：《国际遗传学杂志》2009年第5期329-332,共4页International Journal of Genetics

基　　金：国家自然科学基金项目资助（30850006）

摘　　要：弗林蛋白酶是真核生物中一种广泛参与前体蛋白切割的内切蛋白酶，对分泌途径中许多重要的多肽和蛋白的前体进行剪切加工，使之具有生物活性。在维持机体正常生理过程、参与疾病的病理过程中，弗林蛋白酶起着重要作用。部分心血管活性物质的活化也需要弗林蛋白酶的参与，对维持机体的血压平衡可能起着重要作用。Furin is an endoprotease involved in the process of a wide variety of Precursor Proteins. It cleaves many crucial precursors of peptides and proteins in the secretory pathway, which help the precursors gain their bioactivity. It plays a crucial role in a variety of physiological processes and is involved in the pathology of disease. Furin is responsible for the activation of parts of cardiovascular active material and may play an important role in the maintenance of blood pressure.

关 键 词：弗林蛋白酶 心血管活性物质 

分 类 号：R[医药卫生]