一日两次全身放疗加环磷酰胺预处理方案的毒性和造血恢复  

The toxicity and hematopoietic recovery of preparative regimen with the total body irradiation twice a day plus cyclophosphamide

作　　者：江志生[1] 许康雄[2] 周红[1] 廖辉[1] WILFRED LEE 孙顺平[1] 毛秉智[4] 王学之[1] 罗庆良[4] 陈广文[2] 蔡军伟[1] 徐君[1] 颜美琴[1] 翟振宇[2] 

机构地区：[1]解放军第４５４医院 [2]江苏省肿瘤医院 [3]香港明德医院 [4]解放军军事医学科学院

出　　处：《中华器官移植杂志》1998年第4期243-245,共3页Chinese Journal of Organ Transplantation

摘　　要：一日两次不等剂量全身放疗（ＴＢＩ）加环磷酰胺（ＣＹ）预处理，自体或异基因骨髓移植（ＢＭＴ）或外周血造血干细胞移植（ＰＢＳＴ）治疗１２例恶性血液病。按ＷＨＯ抗癌药毒副反应分度标准分析预处理方案的毒性并积分。结果表明，不同剂量组毒性积分和造血恢复速度无显著差异。较大剂量组移植后复发率较低，但随访时间短。Twelve cases of hematological malignancy were treated with different doses of the total body irradiation (TBI) twice a day plus the high dose of cyclophosphamide (CY) as condition regimen for autologous or allogeneic bone marrow transplantation or blood stem cell transplantation. The toxicity scores of the condition regimen were analyzed according to the toxicity and side effects of WHO grade criterion of anticancer drugs. The results showed that there were no statistically significant difference in the toxicity, hematopoietic recovery in the groups with different doses. The relapse rate in the high dose of TBI group was lower than that in the low dose of TBI group.

关 键 词：骨髓移植 造血干细胞移植 血液肿瘤 预处理 

分 类 号：R733.05[医药卫生—肿瘤] R457.7[医药卫生—临床医学]