胚胎胸腺移植治疗恶性肿瘤的临床观察  

Treatment of late stage malignant tumor by transplantation of embryonic thymus in different regions

作　　者：石正英[1] 董驹[1] 陈国生[1] 隋铁泉[1] 张小平[1] 王国臣[1] 陈志泉 

机构地区：[1]华北煤炭医学院附属医院妇产科

出　　处：《中华器官移植杂志》1998年第4期246-248,共3页Chinese Journal of Organ Transplantation

摘　　要：为了增强恶性肿瘤患者的免疫功能，研究胚胎胸腺移植疗效最佳的移植部位，把２１例晚期胸部恶性肿瘤患者分为Ａ、Ｂ、Ｃ三组，将胚胎胸腺剪成１．０ｃｍ×１．０ｃｍ×０．１５ｃｍ的薄片，分别移植到股前肌群、背膏肓穴肌肉及肾被膜下，移植后半个月、２个月、６个月末梢血淋巴细胞亚群（ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ４／ＣＤ８）及淋巴细胞转换率（ＬＢＴ）与移植前相比，移植后２个月差异显著（Ｐ＜０．０１），患者症状明显改善，生存质量有所提高。移植６个月后，Ｃ组以上诸值与术前相比仍保持较高水平（Ｐ＜０．０１），且症状的改善，生活质量的提高皆优于Ａ、Ｂ两组。结果表明，治疗恶性肿瘤。To find out the optimal location for transplantation of embryonic thymus, 21 cases of late stage thoracic malignant tumor were divided into three groups (A,B,C). Embryonic thymus, cut into 1.0cm×1.0cm×0.15cm pieces, were transplanted in anterofemoral muscles, Gaohuang point muscles, or renal subcapsular space separately. Blood count of subgroup lymphocytes (CD 3,CD 4,CD 8,CD 4/CD 8) and lymphocyte transfer rate (LBT) were increased significantly in all groups 2 months after transplantation, and remained at a higher level ( P <0.01) in group C, but dropped to control level in groups A and B 6 months after transplantation. Symptoms and quality of life were also improved in group C as compared with those in groups A and B. It was concluded that transplantation of embryonic thymus in renal subcapsular space is a better choice for the treatment of malignant tumor.

关 键 词：胸腺移植 肿瘤 移植部位 

分 类 号：R730.56[医药卫生—肿瘤] R655.705[医药卫生—临床医学]