MGMT基因多态性与非霍奇金淋巴瘤遗传易感性的关系  

Genetic susceptibility of single nucleotide polymorphism in MGMT to non-Hodgkin lymphoma

作　　者：杨帆[1] 施静艺[1] 徐岚[1] 任丽娟[2] 张巧花[2] 赵维莅[1] 沈志祥[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院血液科、上海血液学研究所、医学基因组学国家重点实验室,200025 [2]山西省肿瘤医院血液科

出　　处：《中华血液学杂志》2009年第9期622-625,共4页Chinese Journal of Hematology

基　　金：国家高技术研究发展计划（2006AA02A301）;国家自然科学基金（30700335）;教育部新世纪优秀人才支持计划（NCET-07-0556）;上海市科委国际合作项目（08410708800）;霍英东青年教师基金（111035）

摘　　要：目的探讨MGMT及XPA、XPD、XPG基因重要的单核苷酸多态性位点与非霍奇金淋巴瘤发病风险的关系。方法采用分子量阵列技术（Mass—ARRAY）检测73例淋巴瘤患者及500名正常对照中MGMT L84F、MGMT K178R、XPA TSS＋62、XPD K751Q及XPG TSS＋372五个位点的单核苷酸多态性。结果MGMT L84F（T）等位基因的携带者与野生型（CC）相比，发生非霍奇金淋巴瘤的风险显著升高[OR=2．085，95％可信区间（CI）=1．069～4．068，P=0．029]；其中，前者罹患B细胞淋巴瘤的风险是后者的2．403倍（OR=2．403，95％ CI=1．103～5．235，P=0．024）。检测MGMT K178R、XPA TSS＋62、XPD K751Q及XPG TSS＋372未发现与淋巴瘤发病有统计学相关性。结论MGMT L84F单核苷酸多态性可能在非霍奇金淋巴瘤，尤其是B细胞淋巴瘤的发病过程中起着重要作用。Objective To evaluate the relationship between five single nucleotide polymorphism loci in the MGMT, XPA, XPD and XPG genes and the prevalence of non-Hodgkin＇ s lymphoma. Methods A case-control study of 73 lymphoma cases and 500 healthy controls was conducted and the Mass-ARRAY method was applied for detection of MGMT L84F, MGMT K178R, XPA TSS ＋62, XPD K751Q and XPG TSS ＋ 372. Results MGMT L84F （T allele） was associated with an increased risk of non-Hodgkin lymphoma （OR = 2. 085, 95% CI = 1. 069 - 4. 068, P = 0. 029） , mainly in B-cell lymphoma, of which the risk increased by 2.403-fold （ OR = 2. 403, 95% CI = 1. 103 - 5. 235, P = 0. 024）. No statistically significance was found for MGMT K178R,XPA TSS ＋ 62, XPD K751Q and XPG TSS ＋ 372. Conclusion Single nucleotide polymorphism in the MGMT gene may closely related to the occurrence of non-Hodgkin lymphoma, especially of B-ceil subtype.

关 键 词：基因 MGMT 淋巴瘤 非霍奇金 多态性 单核苷酸 

分 类 号：R686[医药卫生—骨科学]