^(13)C-尿素呼气试验诊断幽门螺杆菌感染的研究  

Reliability of ^(13)C-urea breath test(UBT) in detection of Helicobacter pylori infection

作　　者：吴叔明[1] 施尧[1] 刘文忠[1] 张德中[1] 萧树东[1] 向祖琼[1] 

机构地区：[1]上海第二医科大学仁济医院,上海市消化疾病研究所200001

出　　处：《中华消化杂志》1998年第5期263-264,共2页Chinese Journal of Digestion

摘　　要：目的评估13C-尿素呼气试验（13C-UBT）幽门螺杆菌（Hp）感染的可靠性。方法对82例因胃病而行胃镜检查的患者，于胃窦和胃体取多个活检标本作组织学、粘膜涂片和快速尿素酶试验，以决定是否感染Hp，并作13C-UBT。结果13C-UBT的敏感性、特异性、阳性预测值、阴性预测值是与组织学和尿素酶方法检测Hp的检测结果比较而计算得到。13C-尿素呼气试验的敏感性97．92％、特异性100％、阳性预测值100％、阴性预测值97．14％、准确性98．78％。结论13C-尿素呼气试验有高度敏感性和特异性，对确定患者的Hp感染状态是一非常可靠而又无创伤的诊断方法。Objective The aim of the study is to assess the reliability of UBT in detection of H. pylori infection. Method 82 patients were endoscopied and the status of H.pylori was determined by histologic examination and rapid urease test, as well as by 13C-UBT. Comparing with the histologic examination, sensitivity,specificity, positive predictive value(PPV), negative predictive value(NPV) of UBT were calculated. Result The sensitivity, spcificity, PPV and NPV were 97.98%,100%,100% and 97.14% respectively. Conclusion non-invasive 13C-UBT is highly sensitive and specific, and can be used as 'gold standard' for detection of H.pylori infection.

关 键 词：^13C 尿素呼气试验 幽门螺杆菌 诊断 

分 类 号：R573.04[医药卫生—消化系统] R378.99[医药卫生—内科学]