肝X受体与炎症性疾病  

The effects of liver X receptors in inflammatory diseases

作　　者：陈四国[1] 莫中成[1] 唐朝克[1] 

机构地区：[1]南华大学心血管病研究所,动脉硬化学湖南省重点实验,生命科学研究中心,衡阳421001

出　　处：《生命的化学》2009年第5期640-644,共5页Chemistry of Life

基　　金：国家自然科学基金(30470720);湖南省自然科学基金(06jj5058)资助

摘　　要：肝X受体(liver X receptor,LXR)不仅是一种在脂质代谢中起着重要作用的核受体,而且在调控巨噬细胞炎症和免疫应答中也起着十分重要的作用。研究表明,合成的LXR的激动剂可以促进胆固醇的流出、抑制炎症反应,从而阻止动脉粥样硬化、糖尿病等慢性炎症性疾病的发展。LXR在联系代谢和炎症反应中的作用可望为治疗人类的代谢性疾病提供有意义的靶点。Liver X receptors （LXRs） are nuclear receptors that play central roles in lipid metabolism. In addition to their function in lipid metabolism, LXRs have also been found to modulate inflammation and immune responses in macrophages. Studies have demonstrated that synthetic LXRs agonists can promote cholesterol efflux and inhibit inflammation in vivo, thus inhibit the development of chronic inflammatory diseases such as atherosclerosis and diabetes in animal models. The ability of LXRs to integrate metabolic and inflammatory signaling makes them particularly attractive targets for intervention in human metabolic diseases.

关 键 词：肝X受体 炎症性疾病 动脉粥样硬化 糖尿病 

分 类 号：R363[医药卫生—病理学]