阿托伐他汀对老年人颈动脉粥样斑块和血脂的影响  

Effect of atorvastatin on the arteria carotis atheromatous plaque and blood lipid in old people.

作　　者：汪健[1] 秦碧勇[1] 席刚明[1] 

机构地区：[1]郧阳医学院附属人民医院神经内科,湖北省十堰市442000

出　　处：《中国综合临床》2009年第10期1050-1051,共2页Clinical Medicine of China

摘　　要：目的观察阿托他汀对老年人颈动脉斑块和血脂的影响。方法选择颈动脉彩色多普勒检查存在斑块的脑梗死或短暂性脑缺血发作的住院患者57例，给予阿托伐他汀20mg／d口服，连用3个月，测定治疗前后患者颈动脉内径、流速及斑块大小的改变及对患者血脂的影响。结果治疗后患者颈动脉内径[左侧（0．99±0．11）cm、右侧（O．98±0．08）cm]与治疗前[左侧（O．94±0．09）cm、右侧（0．954-0．07）cm]比较有所扩大（P〈0．05），血流动力学得到改善，治疗后颈动脉斑块[左侧（0．57±0．20）cm^2、右侧（0．54±O．18）cm^2]减小，与治疗前[左侧（0．86±0．17）cm^2、右侧（0．82±0．16）cm。]比较差异有统计学意义（P〈0．05），其降低血清TC、TG、LDL-C和升高HDL—c的作用与治疗前比较差异有统计学意义（P均〈0．05）。结论阿托伐他汀在减小颈动脉斑块及调节血脂、改善血流动力学上有较为肯定的作用。Objective To observe the influence of atorvastatin on the arteria carotis atheromatous plaque and blood lipid in old people. Methods 57 hospitalized patients who had cerebral infarction or transient ischemie attack（TIA） were examined for atheromatous plaque by the color Doppler. They were administered atorvastatin 20 mg/d for three months. The changes of diameter of arteria earotis, rate of flow and size of plaque were measured before and after treatment. Results The diameter of artefia earotis was expanded [ left （ 0.99 ± 0. 11 ） cm, fight （0.98 ±0.08 ） cm vs left（0.94 ± 0.09 ） cm, fight （0.95 ± 0.07 ） cm, P 〈 0.05 ], the hemorrheology was improved, the size of plaque was diminished[ left（0.57 ±0.20） cm2 ,right（0.54 ±0.18）cm2 vs left（0.86 ±0.17） cm2 and right（0.82 ±0.16）cm2, P 〈 0.05 ], TC, TG, LDL-C were lowered and HDL-C was elevated with statistical significance （ P 〈 0.05 ）. Conclusions The atorvastatin has positive therapeutica2 effect in diminishing the size of plaque, adjusting blood lipid and improving hemorrheology.

关 键 词：阿托伐他汀 颈动脉粥样斑块 血脂 

分 类 号：R74[医药卫生—神经病学与精神病学]