内皮依赖性超极化因子在血管危险因素中的研究进展  

Research Advancement of Endothelium - Derived Hyperpolarizing Factor in Vascular Risk Factors

作　　者：朱金海[1] 贾瑞鹏[1] 

机构地区：[1]南京医科大学附属南京第一医院泌尿外科,江苏南京210006

出　　处：《解剖与临床》2009年第5期378-380,共3页Anatomy and Clinics

摘　　要：目的：探讨内皮依赖性超极化因子（endothelium—derivedhyperpolarizingfactor，EDHF）与血管危险因素的关系。方法：参阅相关文献，分别简明叙述EDHF与年龄、高血压、糖尿病、高血脂、动脉粥样硬化之间联系。结果：EDHF是继一氧化氮（nitricoxide，NO）和前列环素（prostacyclin，PG12）后发现的第三类内皮源性血管舒张因子，受到年龄、高血压、糖尿病、高血脂、动脉粥样硬化等多种因素影响。结论：EDHF在调节血管紧张度方面有重要作用，并可能成为治疗与内皮功能障碍相关疾病的新靶标。Objective：To explore the latest researches on endothelium derived hyperpolarizing factor （EDHF） in vascular risk factors. Methods：According to pertinent literature, the relationships between EDHF and age, hypertension, diabetes, hypedipidemia, atherosclerosis were described respectively. Results：The EDHF is third type of endothelium - derived vascular relaxing factor following nitric oxide （NO） and prostacyclin （ PGI2）, Age, hypertension, diabetes, high blood lipids, atherosclerosis and etc. affected the level of EDHF. Conclusions：The EDHF is playing an important role in regulation of vascular tone, and will become a new treating tanget about related to endothelium function disturbance.

关 键 词：内皮依赖性超极化因子 血管舒张 危险因素 

分 类 号：R36[医药卫生—病理学]