结肠癌患者血清中IL-21水平分析及临床意义的研究  

The Significance of IL-21 Serum Levels in Colon Cancer Patients

作　　者：张振亚[1] 许颖[2] 张伟[3] 骆盼[1] 于跃明[1] 

机构地区：[1]河北医科大学第四医院,石家庄市050011 [2]石家庄市中医院病理科 [3]河北医科大学基础课教学部

出　　处：《中国肿瘤临床》2009年第18期1054-1056,共3页Chinese Journal of Clinical Oncology

基　　金：河北省科技发展计划基金资助(编号:07276101D-130)

摘　　要：目的:探讨结肠癌患者血清中IL-21水平和患者病理状态及相关因素之间的关系。方法:采用双抗体夹心ABC-ELISA法,随机选取结肠癌患者40例测定结肠癌患者血清IL-21和IFN-γ的浓度;结合患者免疫平衡状态的变化分析IL-21与IFN-γ、年龄、临床分期、病理类型、浸润深度、肿瘤大小和淋巴结转移等因素的相关水平的关系。结果:40例结肠癌患者血清中的IL-21水平与IFN-γ水平之间呈正相关关系;随着患者临床分期的进展、肿瘤浸润深度的增加、肿瘤体积增大及淋巴结转移,IL-21分泌水平虽有不同程度升高,但血清中IFN-γ分泌量未相应增加,结肠癌患者体内免疫平衡向TH2方向漂移。结论:结肠癌患者体内IL-21相对不足,未能有效刺激IFN-γ的分泌增加,从而导致患者体内免疫平衡状态失衡。Objective： To investigate the serum level of IL-21 in colon carcinoma patients and its relationship with the clinical pathologic conditions and related factors. Methods： The levels of IL-21 and IFNy in serum samples from 40 colon carcinoma cases were detected by ABC-ELISA. The relationship of IL-21 with different clinical pathologic factors such as level of IFNγ, gender, age, pathologic stage, pathologic type and lymph node metastasis was investigated. Results： The level of IL-21 in the 40 serum samples was positively correlated with IFNγ. Progression in the clinical pathologic stage was accompanied with increased tumor volume, deeper invasion, and lymph node metastasis. Serum IL-21 level in the colon carcinoma patients increased with the progression of the disease. The immunologic balance tends toward increased T-helper cells in colon carcinoma patients. Conclusion： The level of IL-21 is decreased in colon carcinoma patients, leading to a failure to stimulate IFNγ secretion and an immunologic imbalance.

关 键 词：结肠癌 IL-21 IFN-Γ 免疫平衡 

分 类 号：R735.35[医药卫生—肿瘤]