7-烷氧白杨素衍生物合成及其抗癌活性研究  

Synthesis and Anticancer Activities of 7-Alkoxy Chrysin Derivatives

作　　者：刘毅[1] 赵菲菲[1] 郑兴[1] 姚旭[1] 郑自通[2] 罗星[1] 黄进[1] 刘黎蕊[2] 戴林芝[2] 

机构地区：[1]南华大学药学系,湖南衡阳421001 [2]南华大学药学科研兴趣小组

出　　处：《南华大学学报（医学版）》2009年第5期516-517,531,共3页Journal of Nanhua University(Medical Edition)

基　　金：湖南省自然科学基金(课题编号:07JJ6157);湖南省大学生研究性学习和创新性试验计划项目(课题编号:2008-269-132)资助

摘　　要：目的研究7-烷氧白杨素衍生物的体外抗癌活性。方法合成7-烷氧取代的白杨素衍生物,并通过MTT法检测其对人急性粒细胞性白血病(HL-60)细胞、人结肠癌(HT-29)细胞和人胃癌(SGC-7901)细胞增殖抑制作用。结果合成了6个烷氧取代白杨素衍生物,其中化合物2b对HT-29细胞增殖的抑制作用强于5-Fu;化合物2a、2b、2e、2d对HL-60细胞增殖的抑制作用强于5-Fu。结论7-烷氧白杨素衍生物具有潜在的抗癌活性。Objective To study the anticancer activity of 7 - alkoxy chryain derivatives. Methods 7 - Alkoxy chrysin derivatives were prepared and their antlcancer activities in vitro were evaluated by the standard MTr method. Results Compound 2b showed more stronger activity against HT -29 cells than 5 - Fu, and compound 2a, 2b, 2e, 2d had stronger activity against HL - 60 cells than 5 - Fu. Conclusion 7 - Alkoxy chrysin derivatives possessed the potent anticancer activity.

关 键 词：白杨素 衍生物 抗癌活性 

分 类 号：R979.1[医药卫生—药品]