过氧化体增殖物激活型受体γ配体罗格列酮对荷瘤小鼠的毒副作用  

Effects of PPARγ Ligand Rosiglitazone in the Human Gastric Carcinoma MGC803 Cells Transplanted into Subrenal-capsule of Mice

作　　者：朱理辉[1] 张琍[1] 张明亮[1] 陈方志[1] 

机构地区：[1]南华大学第二附属医院消化内科,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2009年第5期518-520,共3页Journal of Nanhua University(Medical Edition)

基　　金：湖南省卫生厅资助课题(C2003-015)

摘　　要：目的探讨过氧化体增殖物激活型受体γ(PPARγ)配体罗格列酮对人胃癌MGC803细胞荷瘤小鼠的毒副作用。方法建立人胃癌MGC803细胞小鼠肾囊膜下移植瘤模型后,50 mg/kg罗格列酮连续灌胃5天作用于荷瘤小鼠,观察其体重、肝肾功能、血糖和肝肾结构的变化。结果50 mg/kg罗格列酮对荷瘤小鼠血糖、肝脏和肾脏结构及功能无明显影响。结论PPARγ配体50 mg/kg罗格列酮对荷瘤小鼠无明显毒副作用。Objective To investigate the side effects of peroxisome proliferatoractivated receptor-γ （PPARγ） ligand rosiglitazone in vivo of mice which were transplanted the human gastric carcinoma cells line MGC803 into subrenal - capsule. Methods To establish kunming mouse tumor modes of MGC803 cells transplanted into subrenal - capsule and assay the changes including weight, haptic function,renal function,blood sugar, haptic structure and renal structure of the transplanted - tumor mouse which were continuously poured into with 50 mg/kg rosiglitazone for five days. Results 50 mg/kg rosiglitazone have no obvious effect on weight, haptic function,renal function,blood sugar, haptic structure and renal structure of the transplanted - tumor mouse. Conclusion 50 mg/kg PPARγ ligand rosiglitazone has no side effects on the transplanted - tumor mouse.

关 键 词：罗格列酮 MGC803细胞 肿瘤移植 小鼠 毒副作用 

分 类 号：R73-36[医药卫生—肿瘤]